Leonid Tyan, PhD
Associate Research ScientistCards
About
Research
Publications
2026
Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis
Tyan L, Kostiuk V, Diab N, Zenisek D, Khokha M. Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis. Communications Biology 2026 PMID: 42337067, DOI: 10.1038/s42003-026-10039-9.Peer-Reviewed Original ResearchCaveolar Compartmentalization of Pacemaker Signaling Ensures Stable Sinoatrial Rhythmicity Which Is Disrupted in Heart Failure
Lang D, Ni H, Medvedev R, Liu F, Alvarez-Baron C, Tyan L, Turner D, Warden A, Morotti S, Schrauth T, Chanda B, Kamp T, Robertson G, Grandi E, Glukhov A. Caveolar Compartmentalization of Pacemaker Signaling Ensures Stable Sinoatrial Rhythmicity Which Is Disrupted in Heart Failure. JACC Clinical Electrophysiology 2026, 12: 957-976. PMID: 41711620, PMCID: PMC12974990, DOI: 10.1016/j.jacep.2026.01.003.Peer-Reviewed Original Research
2025
TMBIM4 affects left-right patterning via pluripotency exit during gastrulation
Diab N, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha M. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Developmental Biology 2025, 527: 136-146. PMID: 40744297, DOI: 10.1016/j.ydbio.2025.07.018.Peer-Reviewed Original Research
2022
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.Peer-Reviewed Original ResearchCaveolin-3 prevents swelling-induced membrane damage via regulation of I Cl,swell activity
Turner D, Tyan L, DeGuire F, Medvedev R, Stroebel S, Lang D, Glukhov A. Caveolin-3 prevents swelling-induced membrane damage via regulation of I Cl,swell activity. Biophysical Journal 2022, 121: 1643-1659. PMID: 35378081, PMCID: PMC9117929, DOI: 10.1016/j.bpj.2022.04.001.Peer-Reviewed Original Research
2021
Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes
Tyan L, Turner D, Komp K, Medvedev R, Lim E, Glukhov A. Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes. AJP Heart And Circulatory Physiology 2021, 320: h787-h797. PMID: 33416459, PMCID: PMC8082791, DOI: 10.1152/ajpheart.00569.2020.Peer-Reviewed Original Research
2020
A compartmentalized mathematical model of mouse atrial myocytes
Asfaw T, Tyan L, Glukhov A, Bondarenko V. A compartmentalized mathematical model of mouse atrial myocytes. AJP Heart And Circulatory Physiology 2020, 318: h485-h507. PMID: 31951471, PMCID: PMC7099449, DOI: 10.1152/ajpheart.00460.2019.Peer-Reviewed Original Research
2019
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
Laforest B, Dai W, Tyan L, Lazarevic S, Shen K, Gadek M, Broman M, Weber C, Moskowitz I. Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. Journal Of Clinical Investigation 2019, 129: 4937-4950. PMID: 31609246, PMCID: PMC6819107, DOI: 10.1172/jci124231.Peer-Reviewed Original ResearchCaveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis
Egorov Y, Lang D, Tyan L, Turner D, Lim E, Piro Z, Hernandez J, Lodin R, Wang R, Schmuck E, Raval A, Ralphe C, Kamp T, Rosenshtraukh L, Glukhov A. Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis. Journal Of The American Heart Association 2019, 8: e012748. PMID: 31597508, PMCID: PMC6818041, DOI: 10.1161/jaha.119.012748.Peer-Reviewed Original ResearchA calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice
Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, Mazurek S, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia H, Shen L, Broman M, Moskowitz I, Weber C. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. ELife 2019, 8: e41814. PMID: 30896405, PMCID: PMC6428569, DOI: 10.7554/elife.41814.Peer-Reviewed Original Research
Get In Touch
Contacts
Email