2000
Effect of hyperinsulinemia on myocardial amino acid uptake in patients with coronary artery disease
McNulty P, Jacob R, Deckelbaum L, Young L. Effect of hyperinsulinemia on myocardial amino acid uptake in patients with coronary artery disease. Metabolism 2000, 49: 1365-1369. PMID: 11079831, DOI: 10.1053/meta.2000.9510.Peer-Reviewed Original ResearchConceptsBranched-chain amino acidsIschemic heart diseaseMyocardial uptakeArterial plasmaHeart diseaseChronic ischemic heart diseaseCoronary artery diseasePlasma BCAA concentrationsEffect of hyperinsulinemiaMyocardial glucose uptakeNet myocardial uptakeEuglycemic insulin infusionsNet glutamate uptakeOxidative energy substratesPossible salutary effectsBCAA uptakeMyocardial utilizationEuglycemic hyperinsulinemiaArtery diseaseInsulin levelsBCAA concentrationsInsulin infusionAmino acid uptakeAnabolic effectsCardiovascular disease
1999
Insulin-like growth factor I stimulates cardiac myosin heavy chain and actin synthesis in the awake rat
Young L, Renfu Y, Hu X, Chong S, Hasan S, Jacob R, Sherwin R. Insulin-like growth factor I stimulates cardiac myosin heavy chain and actin synthesis in the awake rat. American Journal Of Physiology 1999, 276: e143-e150. PMID: 9886960, DOI: 10.1152/ajpendo.1999.276.1.e143.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IGrowth factor IAwake ratsMyosin heavy chainFactor IContractile protein synthesisIGF-I infusionLow-dose IGFMixed cardiac proteinsCardiac myosin heavy chainMyosin synthesisBlood pressureOvernight fastIntravenous infusionRight ventricleHeavy chainHeart rateHypoglycemic effectFed ratsIGFRatsDirect actionProtein synthesisSalineCardiac proteins
1992
Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart.
Young LH, Dahl DM, Rauner D, Barrett EJ. Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart. Circulation Research 1992, 71: 393-400. PMID: 1628395, DOI: 10.1161/01.res.71.2.393.Peer-Reviewed Original ResearchConceptsMyocardial protein degradationProtein degradationProtein synthesisMyocardial protein turnoverAmino acid replacementsAcid replacementsProtein turnoverEssential amino acidsAmino acidsPhenylalanine balanceAmino acid concentrationsNet myocardial releaseSpecific activityPhenylalanineVivoDegradationAnimalsBasal rateIsotopic steady statePhysiological hyperinsulinemiaTurnover