Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*
Zhang J, Ge R, Matte-Martone C, Goodwin J, Shlomchik WD, Mamula MJ, Kooshkabadi A, Hardy MP, Geller D. Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*. Journal Of Biological Chemistry 2008, 284: 6249-6259. PMID: 19017639, PMCID: PMC2649105, DOI: 10.1074/jbc.m807997200.Peer-Reviewed Original ResearchConceptsHuman glucocorticoid receptorStudies of glucocorticoidsAdrenocortical sizeGR altersEndogenous glucocorticoidsACTH levelsAdrenal axisReceptor knockImmunologic studiesWild-type GRMaintenance of homeostasisCorticosterone levelsGlucocorticoid receptorGlucocorticoidsNovel gainPhysiologic functionMicePathological processesMutant GRGC functionBasal regulationVivoGC physiologyHomologous recombinationHuman diseasesA Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension
Goodwin JE, Zhang J, Geller DS. A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension. Journal Of The American Society Of Nephrology 2008, 19: 1291-1299. PMID: 18434569, PMCID: PMC2440298, DOI: 10.1681/asn.2007080911.Peer-Reviewed Original ResearchConceptsVascular smooth muscleAcute hypertensive responseHypertensive responseKO miceSmooth muscleGC receptorChronic hypertensive responseGlucocorticoid-Induced HypertensionNormal circadian variationBaseline BPTissue-specific knockoutMineralocorticoid receptorMouse modelHypertensionExcess reabsorptionCircadian variationCritical roleMiceReceptorsPromiscuous activationMuscleVivoKnockoutResponseGlucocorticoids