2013
Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish
Ricci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J. Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish. Journal Of Neuroscience 2013, 33: 3131-3134. PMID: 23407967, PMCID: PMC3684625, DOI: 10.1523/jneurosci.4265-12.2013.Peer-Reviewed Original ResearchConceptsHair cellsSynaptic vesicle releaseNeuromast hair cellsLiving zebrafishBiological discoveryIonic channel activityZebrafishVesicle releaseChannel activityPhysiological activityLateral lineJunctional couplingCellsDetailed understandingPatch-clamp recordingsVestibular peripheryFishNeuromastsActivityDiscoveryFirst recording
2012
Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness
Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness. Cell 2012, 148: 716-726. PMID: 22341444, PMCID: PMC3285425, DOI: 10.1016/j.cell.2011.12.027.Peer-Reviewed Original ResearchConceptsAltered reactive oxygen speciesReactive oxygen speciesMitochondrial ribosome functionMitochondrial disease modelTranscription factor E2F1Tissue-specific pathologyROS-dependent activationRibosome functionRRNA methylationMitochondrial stressApoptotic signalingTissue specificityMtDNA mutationsMetabolic signalingAMP kinaseMultiple tissuesMitochondrial dysfunctionOxygen speciesE2F1MethylationSignalingG cellsEnvironmental factorsApoptosisMice exhibit
1993
Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear
Santos-Sacchi J. Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear. Journal Of Neuroscience 1993, 13: 3599-3611. PMID: 8393487, PMCID: PMC6576533, DOI: 10.1523/jneurosci.13-08-03599.1993.Peer-Reviewed Original ResearchConceptsType I spiral ganglion cellsSpiral ganglion cellsOutward K currentsGuinea pig inner earGanglion cellsK currentsSpiral ganglion cell somataTTX-sensitive Na currentsInner earGanglion cell somataSpontaneous spike activityWhole-cell voltage clampNa currentIntrinsic membrane propertiesInner hair cellsSingle-unit studiesSingle-unit activityHalf-maximal amplitudeAfferent innervationCochlear nucleusIntrinsic electrical propertiesVoltage-dependent ionic conductancesCell somataExtracellular ionic environmentSpike activity