2014
Chloride-driven Electromechanical Phase Lags at Acoustic Frequencies Are Generated by SLC26a5, the Outer Hair Cell Motor Protein
Santos-Sacchi J, Song L. Chloride-driven Electromechanical Phase Lags at Acoustic Frequencies Are Generated by SLC26a5, the Outer Hair Cell Motor Protein. Biophysical Journal 2014, 107: 126-133. PMID: 24988347, PMCID: PMC4119270, DOI: 10.1016/j.bpj.2014.05.018.Peer-Reviewed Original Research
2010
Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell
Wu T, Song L, Shi X, Jiang Z, Santos-Sacchi J, Nuttall A. Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell. Hearing Research 2010, 272: 117-124. PMID: 21044673, PMCID: PMC3387680, DOI: 10.1016/j.heares.2010.10.010.Peer-Reviewed Original ResearchConceptsOuter hair cellsTRPV-1 channelsHair cellsPrimary sensory neuronsEffects of capsaicinGuinea pig outer hair cellsSensory neuronsPharmacological actionsCapsaicinPotassium conductancePotent blockerPharmacological propertiesDirect actionNovel actionCochlear amplificationK conductanceAuditory effectsClassic activatorAuditory receptionCellsNociceptionElectromotilityBlockersNew findingsNeuronsThe remarkable cochlear amplifier
Ashmore J, Avan P, Brownell W, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney C, Hudspeth A, Jülicher F, Lindner B, Martin P, Meaud J, Petit C, Santos-Sacchi J, Sacchi J, Canlon B. The remarkable cochlear amplifier. Hearing Research 2010, 266: 1-17. PMID: 20541061, PMCID: PMC6366996, DOI: 10.1016/j.heares.2010.05.001.Peer-Reviewed Original Research
2004
On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin Tributyltin
Song L, Seeger A, Santos-Sacchi J. On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin Tributyltin. Biophysical Journal 2004, 88: 2350-2362. PMID: 15596517, PMCID: PMC1305283, DOI: 10.1529/biophysj.104.053579.Peer-Reviewed Original ResearchConceptsLateral membranesCell’s mechanical activityOuter hair cellsMammalian cochlear amplifierHair cellsMembrane motorMarine mammalsIntact outer hair cellsPotent abilityFood chainNonselective conductanceCl(-) homeostasisPrestinNanomolar concentrationsExtracellular Cl- concentrationCl fluxMembraneCellsNew environmental threatsMammalsChloride effectTributyltinEnvironmental threatsHomeostasisNonlinear capacitance
2001
Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane
Takahashi S, Santos-Sacchi J. Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane. Pflügers Archiv - European Journal Of Physiology 2001, 441: 506-513. PMID: 11212214, DOI: 10.1007/s004240000455.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneLateral membranesOuter hair cell plasma membraneVoltage-dependent motilityMammalian cochlear amplifierOuter hair cell electromotilityMembrane microdomainsGating currentsHair cell electromotilityTurgor pressureOHC motorMolecular motorsElectromotile responseMembraneMotilityCytoskeletonCharge movementBell-shaped distributionMicrodomainsElectromotilityNon-uniform mappingPronase treatmentCochlear amplifierPronase
1999
Distortion Component Analysis of Outer Hair Cell Motility-Related Gating Charge
Takahashi S, Santos-Sacchi J. Distortion Component Analysis of Outer Hair Cell Motility-Related Gating Charge. The Journal Of Membrane Biology 1999, 169: 199-207. PMID: 10354466, DOI: 10.1007/s002329900531.Peer-Reviewed Original Research
1998
Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig
Santos‐Sacchi J, Kakehata S, Takahashi S. Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig. The Journal Of Physiology 1998, 510: 225-235. PMID: 9625879, PMCID: PMC2231020, DOI: 10.1111/j.1469-7793.1998.225bz.x.Peer-Reviewed Original Research
1997
Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation
Santos-Sacchi J, Huang GJ, Wu M. Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation. Biophysical Journal 1997, 73: 1424-1429. PMID: 9284309, PMCID: PMC1181041, DOI: 10.1016/s0006-3495(97)78174-8.Peer-Reviewed Original ResearchConceptsLateral membranesVoltage magnitudeElectrical techniquesAcoustic frequencyKilohertz rangeOuter hair cell functionVoltage-dependent conductancesVoltage sensorPlasma membraneHair cell functionMechanical effectorsSynaptic poleVoltage-dependent currentsMembrane moleculesAuditory functionDense populationCell functionCable propertiesCochlear amplifierOHC motilitySensory receptors
1996
Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge
Kakehata S, Santos-Sacchi J. Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge. Journal Of Neuroscience 1996, 16: 4881-4889. PMID: 8756420, PMCID: PMC6579298, DOI: 10.1523/jneurosci.16-16-04881.1996.Peer-Reviewed Original ResearchConceptsOuter hair cellsEffects of salicylateConcentration-response curvesGuinea pig outer hair cellsOHC motilityAuditory frequency selectivityForm of salicylateHalf-maximal concentrationReversible tinnitusHearing lossDepolarized levelsHair cell motilityComparable groupsHair cellsOuter Hair Cell MotilityInner aspectOuter aspectSubsurface cisternaeTrypsin treatmentMotilityPressure changesHill coefficientSalicylatePresent experimentsVoltage-induced movement
1993
Harmonics of outer hair cell motility
Santos-Sacchi J. Harmonics of outer hair cell motility. Biophysical Journal 1993, 65: 2217-2227. PMID: 8298045, PMCID: PMC1225953, DOI: 10.1016/s0006-3495(93)81247-5.Peer-Reviewed Original ResearchMapping the distribution of the outer hair cell motility voltage sensor by electrical amputation
Huang G, Santos-Sacchi J. Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation. Biophysical Journal 1993, 65: 2228-2236. PMID: 8298046, PMCID: PMC1225954, DOI: 10.1016/s0006-3495(93)81248-7.Peer-Reviewed Original Research
1992
On the frequency limit and phase of outer hair cell motility: effects of the membrane filter
Santos-Sacchi J. On the frequency limit and phase of outer hair cell motility: effects of the membrane filter. Journal Of Neuroscience 1992, 12: 1906-1916. PMID: 1578277, PMCID: PMC6575887, DOI: 10.1523/jneurosci.12-05-01906.1992.Peer-Reviewed Original Research
1991
Reversible inhibition of voltage-dependent outer hair cell motility and capacitance
Santos-Sacchi J. Reversible inhibition of voltage-dependent outer hair cell motility and capacitance. Journal Of Neuroscience 1991, 11: 3096-3110. PMID: 1941076, PMCID: PMC6575435, DOI: 10.1523/jneurosci.11-10-03096.1991.Peer-Reviewed Original Research
1989
Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti
Santos-Sacchi J. Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti. Journal Of Neuroscience 1989, 9: 2954-2962. PMID: 2769373, PMCID: PMC6569687, DOI: 10.1523/jneurosci.09-08-02954.1989.Peer-Reviewed Original ResearchConceptsOuter hair cellsWhole-cell voltage-clamp techniqueHair cellsNormal resting potentialsOrgan of CortiVoltage-clamp techniqueCell shorteningAcoustic stimulationReceptor potentialResting potentialsResponse magnitudeOHC movementsReported productionStimulationHyperpolarizationComparable levelsNeural tuningCell length changesDepolarizationLength changesCellsBasilar membraneVoltage stimulation
1988
Whole cell currents and mechanical responses of isolated outer hair cells
Santos-Sacchi J, Dilger J. Whole cell currents and mechanical responses of isolated outer hair cells. Hearing Research 1988, 35: 143-150. PMID: 2461927, DOI: 10.1016/0378-5955(88)90113-x.Peer-Reviewed Original Research