2019
Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. Journal Of Neuroscience 2019, 39: 4797-4813. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysAuditory PerceptionBrain StemCochlear NucleusElectrophysiological PhenomenaEvoked Potentials, Auditory, Brain StemFemaleFragile X Mental Retardation ProteinFragile X SyndromeHydantoinsIn Vitro TechniquesMaleMiceMice, KnockoutPatch-Clamp TechniquesPyridinesShaw Potassium ChannelsConceptsAuditory brainstem responseWild-type animalsRepetitive firingABR wave ICurrent-clamp recordingsAuditory brainstem nucleiVoltage-clamp recordingsHigh-frequency firingSingle action potentialFragile X syndromeTrapezoid bodyBrainstem nucleiBrainstem responseMedial nucleusAuditory brainstemAuditory nerveWave IWave IVAction potentialsSensory stimuliKv3.1 channelsCentral processingMental retardation proteinHigh sound levelsMice
2013
Chapter 25 Audition
Brown M, Santos-Sacchi J. Chapter 25 Audition. 2013, 553-576. DOI: 10.1016/b978-0-12-385870-2.00025-1.Peer-Reviewed Original ResearchHair cellsOuter hair cellsMore apical locationsCochlear nucleusMedial geniculateNerve fibersAuditory brainstemAuditory cortexInferior colliculusAuditory nerveSuperior oliveComplex sound stimuliSensitivity of hearingCochlear implantsInteraural level differencesInner earCentral pathwaysReceptor cellsSound stimuliAuditory systemInteraural timeSound localizationIon channelsApical locationMechanoreceptors