2012
Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision
Estevez ME, Fogerson PM, Ilardi MC, Borghuis BG, Chan E, Weng S, Auferkorte ON, Demb JB, Berson DM. Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision. Journal Of Neuroscience 2012, 32: 13608-13620. PMID: 23015450, PMCID: PMC3474539, DOI: 10.1523/jneurosci.1422-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBeta-GalactosidaseCholera ToxinCholine O-AcetyltransferaseDendritesElectroretinographyFemaleGeniculate BodiesGreen Fluorescent ProteinsLightMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicPatch-Clamp TechniquesPhotic StimulationRetinaRetinal Ganglion CellsRod OpsinsVisual CortexVisual FieldsVisual PathwaysConceptsM4 cellsM2 cellsDorsal lateral geniculate nucleusPhotosensitive retinal ganglion cellsInner plexiform layerRetinal ganglion cellsLateral geniculate nucleusRetinal output neuronsNonlinear spatial summationCholinergic bandDendritic stratificationON sublaminaLarge somataPlexiform layerGanglion cellsDendritic arborsGeniculate nucleusPhotopigment melanopsinVentral retinaDorsal retinaMouse retinaDirection selectivityFunctional rodsCentral projectionsM3 cells
2008
Functional circuitry of visual adaptation in the retina
Demb JB. Functional circuitry of visual adaptation in the retina. The Journal Of Physiology 2008, 586: 4377-4384. PMID: 18617564, PMCID: PMC2614018, DOI: 10.1113/jphysiol.2008.156638.Peer-Reviewed Original ResearchConceptsPresynaptic bipolar cellsGanglion cellsReceptive field centerBipolar cellsGanglion cell receptive field centersPeripheral receptive fieldsBipolar cell inputsContrast adaptationRetinal ganglion cellsBipolar terminalsGlutamate releaseAmacrine cellsSynaptic outputMammalian retinaContrast stimulationFunctional circuitryCellular mechanismsSpike generationCell inputHyperpolarizationReceptive fieldsRetinaResponse saturationField centerCells
2007
Functional Circuitry for Peripheral Suppression in Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Manookin MB, Borghuis BG, Boahen K, Demb JB. Functional Circuitry for Peripheral Suppression in Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neurophysiology 2007, 97: 4327-4340. PMID: 17460102, DOI: 10.1152/jn.01091.2006.Peer-Reviewed Original ResearchConceptsAmacrine cellsGanglion cellsCenter responseSynaptic layersY-type retinal ganglion cellsHorizontal cellsY-type ganglion cellsSecond synaptic layerGanglion cell receptive fieldsRetinal ganglion cellsGuinea pig retinaStimulus-response curvesRetinal ganglion cell receptive fieldsFirst synaptic layerCurrent-clamp conditionsBipolar terminalsGlutamate releaseCell receptive fieldsPeripheral gratingsPeripheral suppressionIntracellular recordingsPig retinaSubthreshold membrane potentialsExcitatory centerInhibitory conductanceCellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells
Beaudoin DL, Borghuis BG, Demb JB. Cellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells. Journal Of Neuroscience 2007, 27: 2636-2645. PMID: 17344401, PMCID: PMC6672510, DOI: 10.1523/jneurosci.4610-06.2007.Peer-Reviewed Original ResearchConceptsReceptive field centerPresynaptic bipolar cellsGanglion cellsBipolar cellsAmacrine cellsGanglion cell receptive field centersContrast gain controlMammalian retinal ganglion cellsMammalian ganglion cellsRetinal ganglion cellsWhole-cell recordingsInhibitory neurotransmitter receptorsField centerVoltage-clamp conditionsInhibitory interneuronsSynaptic releaseNeurotransmitter receptorsCenter responseExtracellular recordingsPharmacological conditionsAdequate stimulationInhibitory conductanceCalcium bufferingSubthreshold responsesMembrane currents
1999
Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field
Demb J, Haarsma L, Freed M, Sterling P. Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field. Journal Of Neuroscience 1999, 19: 9756-9767. PMID: 10559385, PMCID: PMC6782950, DOI: 10.1523/jneurosci.19-22-09756.1999.Peer-Reviewed Original ResearchConceptsGanglion cellsDendritic fieldsContrast-reversing gratingsNonlinear receptive fieldsOFF ganglion cellsReceptive fieldsCell dendritic fieldsRetinal ganglion cellsGuinea pig retinaBipolar cell responsesReceptive field mechanismsSurround responsesBipolar cellsPig retinaCell responsesFunctional circuitryL-APVisual stimuliMembrane potentialSingle classCellsResponseInterneuronsTetrodotoxinRetina