2018
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
Yao K, Qiu S, Wang YV, Park SJH, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature 2018, 560: 484-488. PMID: 30111842, PMCID: PMC6107416, DOI: 10.1038/s41586-018-0425-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninBlindnessCell CycleCell ProliferationCellular ReprogrammingDisease Models, AnimalFemaleGTP-Binding Protein alpha SubunitsHeterotrimeric GTP-Binding ProteinsMaleMiceNeurogenesisNeurogliaRegenerative MedicineRetinal Rod Photoreceptor CellsStem CellsTranscription FactorsTransducinVisual CortexVisual PathwaysConceptsMüller gliaGene transferMG proliferationRod photoreceptorsMammalian retinaCell fate specificationPopulations of stemSubsequent gene transferFate specificationRetinal stem cellsTranscription factorsRetinal neuronsCell cycleDouble mutant miceRegenerative machineryDe novo genesisΒ-cateninStem cellsProgenitor cellsRestoration of visionPrimary visual cortexMutant miceAbsence of injuryPhotoreceptorsRetinal injury
2012
Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision
Estevez ME, Fogerson PM, Ilardi MC, Borghuis BG, Chan E, Weng S, Auferkorte ON, Demb JB, Berson DM. Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision. Journal Of Neuroscience 2012, 32: 13608-13620. PMID: 23015450, PMCID: PMC3474539, DOI: 10.1523/jneurosci.1422-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBeta-GalactosidaseCholera ToxinCholine O-AcetyltransferaseDendritesElectroretinographyFemaleGeniculate BodiesGreen Fluorescent ProteinsLightMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicPatch-Clamp TechniquesPhotic StimulationRetinaRetinal Ganglion CellsRod OpsinsVisual CortexVisual FieldsVisual PathwaysConceptsM4 cellsM2 cellsDorsal lateral geniculate nucleusPhotosensitive retinal ganglion cellsInner plexiform layerRetinal ganglion cellsLateral geniculate nucleusRetinal output neuronsNonlinear spatial summationCholinergic bandDendritic stratificationON sublaminaLarge somataPlexiform layerGanglion cellsDendritic arborsGeniculate nucleusPhotopigment melanopsinVentral retinaDorsal retinaMouse retinaDirection selectivityFunctional rodsCentral projectionsM3 cells
2005
Do We Know What the Early Visual System Does?
Carandini M, Demb JB, Mante V, Tolhurst DJ, Dan Y, Olshausen BA, Gallant JL, Rust NC. Do We Know What the Early Visual System Does? Journal Of Neuroscience 2005, 25: 10577-10597. PMID: 16291931, PMCID: PMC6725861, DOI: 10.1523/jneurosci.3726-05.2005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1999
Motion Opponency in Visual Cortex
Heeger D, Boynton G, Demb J, Seidemann E, Newsome W. Motion Opponency in Visual Cortex. Journal Of Neuroscience 1999, 19: 7162-7174. PMID: 10436069, PMCID: PMC6782843, DOI: 10.1523/jneurosci.19-16-07162.1999.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVisual motion perceptionMotion opponencyMotion perceptionVisual cortexSecondary visual cortical areasHuman MT complexHuman visual cortexDirection-selective signalsVisual cortical areasSensitive brain areasPrimary visual cortexMacaque monkey brainMagnetic resonance imagingPopulations of neuronsMultiunit electrophysiological recordingsBrain activityPerceptual studiesNeuronal correlatesFMRI measurementsArea MTCortical areasBrain areasMonkey brainResonance imagingNeuronal basis of contrast discrimination
Boynton G, Demb J, Glover G, Heeger D. Neuronal basis of contrast discrimination. Vision Research 1999, 39: 257-269. PMID: 10326134, DOI: 10.1016/s0042-6989(98)00113-8.Peer-Reviewed Original ResearchMeSH KeywordsContrast SensitivityHumansMagnetic Resonance ImagingPhotic StimulationPsychophysicsVisual CortexConceptsVisual cortical areasAverage neuronal activityFunctional magnetic resonance imagingFMRI responsesNeuronal activityCortical areasEarly visual cortical areasMagnetic resonance imagingVisual areas V1Contrast increment thresholdsIncrement thresholdsEarly visual cortexNeuronal responsesBrain areasVisual cortexResonance imagingArea V1Neuronal basisPooled activityStimulus intervalStimulus contrastBaseline contrastNeuronal signalsBrain activityHuman brain activity
1997
Brain activity in visual cortex predicts individual differences in reading performance
Demb J, Boynton G, Heeger D. Brain activity in visual cortex predicts individual differences in reading performance. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 13363-13366. PMID: 9371851, PMCID: PMC24314, DOI: 10.1073/pnas.94.24.13363.Peer-Reviewed Original ResearchConceptsBrain activityIndividual differencesSpecific visual pathwaysM pathwayCortical visual areasPrimary visual cortexFunctional magnetic resonance imagingMagnetic resonance imagingPathway abnormalitiesVisual cortexVisual pathwayResonance imagingVisual areasMagnocellular pathwayReading abilityPathway inputSignificant correlationReduced activityDyslexicsDyslexiaPathwayStrong relationshipActivityAbnormalitiesCortex