2024
Specific retinal neurons regulate context-dependent defensive responses to visual threat
Lee T, Weinberg-Wolf H, Zapadka T, Rudenko A, Demb J, Kim I. Specific retinal neurons regulate context-dependent defensive responses to visual threat. PNAS Nexus 2024, 3: pgae423. PMID: 39359403, PMCID: PMC11443969, DOI: 10.1093/pnasnexus/pgae423.Peer-Reviewed Original ResearchRetinal ganglion cellsBehavioral responsesRetinal ganglion cell typesVisual threatAlpha retinal ganglion cellsLooming stimuliThreatening stimuliMature miceGanglion cellsBehavioral reactionsUnique contributionsCell ablationVisual pathwayOutput neuronsEarly visual pathwayStimuliContextual signalsDefense responsesAerial predatorsEnvironmental context
2008
Disinhibition Combines with Excitation to Extend the Operating Range of the OFF Visual Pathway in Daylight
Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB. Disinhibition Combines with Excitation to Extend the Operating Range of the OFF Visual Pathway in Daylight. Journal Of Neuroscience 2008, 28: 4136-4150. PMID: 18417693, PMCID: PMC2557439, DOI: 10.1523/jneurosci.4274-07.2008.Peer-Reviewed Original ResearchConceptsOFF ganglion cellsAII amacrine cellsCone bipolar cellsGanglion cellsAmacrine cellsAII cellsBipolar cellsPresence of CNQXBipolar cell synapsesD-APOFF visual pathwayBipolar cell pathwaysGap junctionsGlycine releaseExcitatory responsesIonotropic glutamateSynaptic inhibitionCell synapsesON pathwayGlycine receptorsLight decrementsVisual pathwayElectrical synapsesMeclofenamic acidDaylight vision
2005
Do We Know What the Early Visual System Does?
Carandini M, Demb JB, Mante V, Tolhurst DJ, Dan Y, Olshausen BA, Gallant JL, Rust NC. Do We Know What the Early Visual System Does? Journal Of Neuroscience 2005, 25: 10577-10597. PMID: 16291931, PMCID: PMC6725861, DOI: 10.1523/jneurosci.3726-05.2005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1999
Normal planum temporale asymmetry in dyslexics with a magnocellular pathway deficit
Best M, Demb J. Normal planum temporale asymmetry in dyslexics with a magnocellular pathway deficit. Neuroreport 1999, 10: 607-612. PMID: 10208598, DOI: 10.1097/00001756-199902250-00030.Peer-Reviewed Original ResearchConceptsPlanum temporalePT asymmetryPlanum temporale asymmetrySagittal magnetic resonance imagesMagnocellular visual pathwayMagnocellular deficitVisual pathwayAbnormal symmetryDifferent subtypesPathway deficitsMagnetic resonance imagesSubject groupsMagnocellular pathway deficitDyslexic subjectsResonance imagesDeficitsSubjectsHemispheric symmetryGroupAbnormalitiesSubtypes
1998
Functional Magnetic Resonance Imaging of Early Visual Pathways in Dyslexia
Demb J, Boynton G, Heeger D. Functional Magnetic Resonance Imaging of Early Visual Pathways in Dyslexia. Journal Of Neuroscience 1998, 18: 6939-6951. PMID: 9712663, PMCID: PMC6792964, DOI: 10.1523/jneurosci.18-17-06939.1998.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingBrain activityResonance imagingM pathwayReduced brain activityPrimary visual cortexMotion-sensitive areasSpeed discriminationPerceptual thresholdHigher V1Pathway abnormalitiesVisual motion perceptionEarly visual pathwayGroups of dyslexicsVisual cortexVisual pathwayLower perceptual thresholdsExtrastriate areasArea MTMagnocellular pathwayStimulus speedPathway inputEarly visual systemNormal readers
1997
Brain activity in visual cortex predicts individual differences in reading performance
Demb J, Boynton G, Heeger D. Brain activity in visual cortex predicts individual differences in reading performance. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 13363-13366. PMID: 9371851, PMCID: PMC24314, DOI: 10.1073/pnas.94.24.13363.Peer-Reviewed Original ResearchConceptsBrain activityIndividual differencesSpecific visual pathwaysM pathwayCortical visual areasPrimary visual cortexFunctional magnetic resonance imagingMagnetic resonance imagingPathway abnormalitiesVisual cortexVisual pathwayResonance imagingVisual areasMagnocellular pathwayReading abilityPathway inputSignificant correlationReduced activityDyslexicsDyslexiaPathwayStrong relationshipActivityAbnormalitiesCortex