2001
Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats
Bergeron R, Previs S, Cline G, Perret P, Russell III R, Young L, Shulman G. Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats. Diabetes 2001, 50: 1076-1082. PMID: 11334411, DOI: 10.2337/diabetes.50.5.1076.Peer-Reviewed Original ResearchMeSH KeywordsAdenylate KinaseAminoimidazole CarboxamideAnimalsBlood GlucoseBody WeightFatty Acids, NonesterifiedGlucoseGlycerolInfusions, IntravenousInjections, IntravenousInsulinInsulin ResistanceLactatesMaleModels, AnimalMuscle, SkeletalObesityRatsRats, ZuckerReference ValuesRibonucleotidesTriglyceridesConceptsWhole-body glucose disposalInsulin-resistant rat modelObese ratsEndogenous glucose productionObese Zucker ratsRed gastrocnemius muscleInsulin infusion rateLean ratsGlucose disposalInsulin infusionRat modelInfusion rateGastrocnemius muscleZucker ratsLipid metabolismGlucose productionEndogenous glucose production rateGlucose transport activitySkeletal muscle glucose transport activityType 2 diabetesWhole-body carbohydrateInsulin-stimulated glucose uptakeInsulin-independent pathwaySkeletal muscle AMPKGlucose production rate
1985
Metabolic Response to Three Years of Continuous, Basal Rate Intravenous Insulin Infusion in Type II Diabetic Patients*
BLACKSHEAR P, SHULMAN G, ROUSSELL A, NATHAN D, MINAKER K, ROWE J, ROBBINS D, COHEN A. Metabolic Response to Three Years of Continuous, Basal Rate Intravenous Insulin Infusion in Type II Diabetic Patients*. The Journal Of Clinical Endocrinology & Metabolism 1985, 61: 753-760. PMID: 3897260, DOI: 10.1210/jcem-61-4-753.Peer-Reviewed Original ResearchConceptsType II diabetic patientsII diabetic patientsInsulin clamp studiesDiabetic patientsInsulin infusionClamp studiesObese type II diabetic patientsEuglycemic insulin clamp studiesInfusion pumpVitreous fluorescein concentrationHemoglobin A1c levelsMonths of treatmentGlucose disposal rateIntravenous insulin infusionNormal glycemic controlSerum triglyceride concentrationBlood glucose levelsInfusion of insulinImplantable infusion pumpInsulin infusion pumpA1c levelsGlycemic controlSignificant hypoglycemiaImmunoreactive insulinPlasma glucose