2000
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova O, Marcus-Samuels B, Graham D, Kim J, Shulman G, Castle A, Vinson C, Eckhaus M, Reitman M. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. Journal Of Clinical Investigation 2000, 105: 271-278. PMID: 10675352, PMCID: PMC377444, DOI: 10.1172/jci7901.Peer-Reviewed Original ResearchConceptsA-ZIP/FLipoatrophic diabetesAdipose tissueNear-physiological amountsMuscle insulin sensitivityLack of fatLipoatrophic miceInsulin levelsHepatic steatosisInsulin resistanceInsulin sensitivitySevere formFFA levelsDiabetesDonor fatTransplantationBeneficial effectsEndocrine communicationSubcutaneous sitesMiceSurgical implantationAdipose physiologyHyperglycemiaFatTissue
1999
Cellular mechanisms of insulin resistance in humans
Shulman G. Cellular mechanisms of insulin resistance in humans. The American Journal Of Cardiology 1999, 84: 3-10. PMID: 10418851, DOI: 10.1016/s0002-9149(99)00350-1.Peer-Reviewed Original ResearchConceptsType 2 diabetesInsulin resistanceMuscle glycogen synthesisFree fatty acidsGlucose productionHepatic gluconeogenesisInsulin-stimulated glucose metabolismInsulin-stimulated muscle glycogen synthesisBetter glucose controlCellular mechanismsHepatic glucose productionLiver glycogen concentrationGlycogen synthesisPathophysiologic defectsCombination therapyGlucose controlInsulin secretionInsulin receptor substrateHyperinsulinemic clampingPeripheral tissuesGlucose clearanceFFA levelsGlucose metabolismThiazolidinedione troglitazoneDiabetes
1998
Effect of insulin on glycerol production in obese adolescents
Robinson C, Tamborlane W, Maggs D, Enoksson S, Sherwin R, Silver D, Shulman G, Caprio S. Effect of insulin on glycerol production in obese adolescents. American Journal Of Physiology 1998, 274: e737-e743. PMID: 9575836, DOI: 10.1152/ajpendo.1998.274.4.e737.Peer-Reviewed Original ResearchConceptsNet lipid oxidationObese adolescentsLean adultsGlycerol turnoverTwo-step euglycemic-hyperinsulinemic clampFree fatty acid concentrationsBody fat massEuglycemic hyperinsulinemic clampSensitivity of adipocytesEffect of insulinAction of insulinObese groupLean subjectsInsulin resistanceAdipose massPlasma insulinFatty acid concentrationsAdolescent obesityFat massLean adolescentsImpaired stimulationPhysiological incrementsFFA levelsGlucose metabolismIndirect calorimetry