2021
323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart
GOEDEKE L, LEE J, MA Y, HU X, ZHANG J, DONG J, GALSGAARD K, GUERRERA N, HAEDERSDAL S, ZHANG X, PERRY R, CLINE G, YOUNG L, SHULMAN G. 323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart. Diabetes 2021, 70 DOI: 10.2337/db21-323-or.Peer-Reviewed Original ResearchPlasma glucose concentrationDAPA treatmentHeart failureAwake male Sprague-Dawley ratsMajor adverse cardiovascular eventsMale Sprague-Dawley ratsRecent clinical outcome studiesAdverse cardiovascular eventsHeart failure ratsType 2 diabetesClinical outcome studiesSprague-Dawley ratsGlucose concentrationΒOHB levelsCardiovascular eventsCardiovascular benefitsVehicle treatmentPermanent ligationSGLT2 inhibitorsCoronary arteryControl ratsKetone utilizationDawley ratsAcute effectsFailing Heart
1997
Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis
Petersen K, Jacob R, West A, Sherwin R, Shulman G. Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis. American Journal Of Physiology 1997, 273: e1189-e1193. PMID: 9435535, DOI: 10.1152/ajpendo.1997.273.6.e1189.Peer-Reviewed Original ResearchConceptsMuscle glycogen synthesisInsulin-like growth factor ICirrhotic ratsGrowth factor IGlucose metabolismLiver cirrhosisGlycogen synthesisFactor IInsulin-stimulated muscle glycogen synthesisIGF-I therapyPeripheral glucose metabolismWhole-body glucose turnoverEndogenous glucose productionAbility of IGFEuglycemic clampInsulin resistanceControl ratsAwake ratsCirrhosisDiminished suppressionControl groupIGFRatsGlucose productionGlucose turnover
1992
Simultaneous Insulinlike Growth Factor I and Insulin Resistance in Obese Zucker Rats
Jacob R, Sherwin R, Greenawalt K, Shulman G. Simultaneous Insulinlike Growth Factor I and Insulin Resistance in Obese Zucker Rats. Diabetes 1992, 41: 691-697. PMID: 1587396, DOI: 10.2337/diab.41.6.691.Peer-Reviewed Original ResearchConceptsInsulinlike growth factor IGrowth factor IObese Zucker ratsObese ratsLean ratsZucker ratsChain amino acid concentrationsFactor IGlucose uptakeIGF-I infusionDiabetic BB ratsIGF-I levelsEffects of IGFEuglycemic insulin clampLean control ratsObese groupBB ratsInsulin clampInsulin resistanceLean controlsControl ratsRats 6Amino acid concentrationsVivo effectsIGF