The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M, Giaveri G, Arosio P, Santambrogio P, Fariello R, Karatekin E, Kleinman M, Turro N, Hornykiewicz O, Zucca F. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 9843-9848. PMID: 15210960, PMCID: PMC470762, DOI: 10.1073/pnas.0403495101.Peer-Reviewed Original ResearchConceptsSubstantia nigraLocus coeruleusLC neuronsNeuronal vulnerabilityParkinson's diseaseCopper/zinc SODZinc SODCompacta neuronsParkinsonian syndromesBrainstem nucleiManganese superoxide dismutaseGlial cellsMajor molecular formCeruloplasmin levelsNormal subjectsRelated disordersRole of ironLight chain ferritinNeuronsDiseaseManganese SODFerritinNeuromelaninCoeruleusNM concentrations