Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
Sulzer D, Bogulavsky J, Larsen K, Behr G, Karatekin E, Kleinman M, Turro N, Krantz D, Edwards R, Greene L, Zecca L. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 11869-11874. PMID: 11050221, PMCID: PMC17261, DOI: 10.1073/pnas.97.22.11869.Peer-Reviewed Original ResearchConceptsCytosolic catecholaminesSubstantia nigraDisease neurodegenerationCytosolic dopamineRat substantia nigraSynaptic vesiclesParkinson's disease neurodegenerationHuman substantia nigraIron chelator desferrioxamineCatecholamine neuronsFunction of neuromelaninDeep brain regionsParkinson's diseaseAdenoviral-mediated overexpressionBrain regionsDouble-membrane autophagic vacuolesVesicular accumulationPC12 cell culturesChelator desferrioxamineDopamineNM granulesAntioxidant mechanismsPC12 cellsNeuromelaninNeurite outgrowth