2023
Ground squirrels – experts in thermoregulatory adaptation
Feketa V, Bagriantsev S, Gracheva E. Ground squirrels – experts in thermoregulatory adaptation. Trends In Neurosciences 2023, 46: 505-507. PMID: 37188617, DOI: 10.1016/j.tins.2023.04.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHuman TRPV1 structure and inhibition by the analgesic SB-366791
Neuberger A, Oda M, Nikolaev Y, Nadezhdin K, Gracheva E, Bagriantsev S, Sobolevsky A. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14: 2451. PMID: 37117175, PMCID: PMC10147690, DOI: 10.1038/s41467-023-38162-9.Peer-Reviewed Original ResearchConceptsSB-366791Transient receptor potential (TRP) ion channelsPotential ion channelsPain pathwaysPain therapyPain treatmentPsychiatric disordersOpioid crisisTherapy targetTRPV1 inhibitorElectrophysiological recordingsHuman TRPV1TRP channelsTRPV1New drugsDisease conditionsVanilloid subfamilyIon channelsTreatmentInhibitorsOpioidsPainTherapyDiseaseCryo-electron microscopy structure
2016
Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels
Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11342-11347. PMID: 27638213, PMCID: PMC5056056, DOI: 10.1073/pnas.1604269113.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAmino Acid SequenceAmino Acid SubstitutionAnimalsAnkyrin RepeatCamelusCapsaicinConserved SequenceGanglia, SpinalHEK293 CellsHot TemperatureHumansHydrogen-Ion ConcentrationIon Channel GatingMutationNeuronsSciuridaeSequence AlignmentThermotoleranceTRPV Cation ChannelsXenopusConceptsHeat toleranceCommon molecular strategyN-terminal ankyrinSingle amino acid changeSingle amino acid substitutionGround squirrelsPolymodal ion channelAmino acid changesAmino acid substitutionsRemarkable functional flexibilityFunctional conservationEcological nichesChemical cuesMammalian speciesMolecular strategiesAcid changesAcid substitutionsHeat sensitivityTransient receptor potential vanilloid 1Ion channelsOrthologsFunctional plasticitySquirrelsBactrian camelsSuch adaptation
2011
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature 2011, 476: 88-91. PMID: 21814281, PMCID: PMC3535012, DOI: 10.1038/nature10245.Peer-Reviewed Original ResearchConceptsVampire batsGene sequencesWarm-blooded preyGroup of snakesDifferent molecular mechanismsVertebrate lineageRNA splicingMolecular dataSensitive ion channelsMolecular mechanismsIon channelsBatsHeat-sensitive channelSplicingPit organsSnakesLineagesPreySequenceHot spotsDolphinsUnderliesRodentsVariants
2002
Activation of p38 MAP-Kinase and Caldesmon Phosphorylation Are Essential for Urokinase-Induced Human Smooth Muscle Cell Migration
Goncharova E, Vorotnikov A, Gracheva E, Wang C, Panettieri R, Stepanova V, Tkachuk V. Activation of p38 MAP-Kinase and Caldesmon Phosphorylation Are Essential for Urokinase-Induced Human Smooth Muscle Cell Migration. Biological Chemistry 2002, 383: 115-126. PMID: 11930938, DOI: 10.1515/bc.2002.012.Peer-Reviewed Original ResearchMeSH KeywordsCalmodulin-Binding ProteinsCell MovementHumansKringlesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesMuscle, Smooth, VascularP38 Mitogen-Activated Protein KinasesPhosphorylationProtein Structure, TertiaryRecombinant ProteinsTracheaUrokinase-Type Plasminogen ActivatorConceptsP38 MAP kinaseMAP kinaseUPA mutantsKringle domainsHuman airway smooth muscle cellsSmooth muscle cell migrationCaldesmon phosphorylationMuscle cell migrationMAP kinase sitesP38 MAP kinase pathwayCell migrationNon-muscle caldesmonMAP kinase pathwayMAP kinase activationP38 MAP kinase activationMyosin regulatory light chainHuman smooth muscle cell migrationUrokinase-type plasminogen activatorRegulatory light chainProtein caldesmonCell motilityDownstream phosphorylationSer-19PhosphorylationIntracellular pathways