2017
Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
Matos-Cruz V, Schneider ER, Mastrotto M, Merriman DK, Bagriantsev SN, Gracheva EO. Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters. Cell Reports 2017, 21: 3329-3337. PMID: 29262313, PMCID: PMC5741102, DOI: 10.1016/j.celrep.2017.11.083.Peer-Reviewed Original ResearchConceptsTransmembrane domainCold toleranceCold sensitivityGround squirrelsRat orthologMolecular adaptationsMammalian hibernatorsReciprocal mutationsAmino acidsFunctional significanceOrthologsSquirrelsMolecular prerequisitesActive stateHibernatorsTRPM8Somatosensory neuronsTolerancePoor activationSpeciesDomainMutationsResiduesHibernationCells
2002
Activation of p38 MAP-Kinase and Caldesmon Phosphorylation Are Essential for Urokinase-Induced Human Smooth Muscle Cell Migration
Goncharova E, Vorotnikov A, Gracheva E, Wang C, Panettieri R, Stepanova V, Tkachuk V. Activation of p38 MAP-Kinase and Caldesmon Phosphorylation Are Essential for Urokinase-Induced Human Smooth Muscle Cell Migration. Biological Chemistry 2002, 383: 115-126. PMID: 11930938, DOI: 10.1515/bc.2002.012.Peer-Reviewed Original ResearchMeSH KeywordsCalmodulin-Binding ProteinsCell MovementHumansKringlesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesMuscle, Smooth, VascularP38 Mitogen-Activated Protein KinasesPhosphorylationProtein Structure, TertiaryRecombinant ProteinsTracheaUrokinase-Type Plasminogen ActivatorConceptsP38 MAP kinaseMAP kinaseUPA mutantsKringle domainsHuman airway smooth muscle cellsSmooth muscle cell migrationCaldesmon phosphorylationMuscle cell migrationMAP kinase sitesP38 MAP kinase pathwayCell migrationNon-muscle caldesmonMAP kinase pathwayMAP kinase activationP38 MAP kinase activationMyosin regulatory light chainHuman smooth muscle cell migrationUrokinase-type plasminogen activatorRegulatory light chainProtein caldesmonCell motilityDownstream phosphorylationSer-19PhosphorylationIntracellular pathways