2009
Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes
Homma R, Baker BJ, Jin L, Garaschuk O, Konnerth A, Cohen LB, Zecevic D. Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes. Philosophical Transactions Of The Royal Society B Biological Sciences 2009, 364: 2453-2467. PMID: 19651647, PMCID: PMC2865128, DOI: 10.1098/rstb.2009.0084.Peer-Reviewed Original ResearchConceptsCalcium-sensitive dyeVoltage-sensitive dyeDendrites of neuronsComplex synaptic inputsDorsal brainstemCell typesBrainstem preparationBath applicationSynaptic inputsRespiratory rhythmSpike activityTwo-photon imagingMammalian brainIon-sensitive dyesIndividual neuronsTwo-photon microscopyPopulation signalsBrainstemBrain activityIndividual cell typesNeuronsBrainMembrane potentialOutput spike trainsSpike trainsWide-Field and Two-Photon Imaging of Brain Activity with Voltage and Calcium-Sensitive Dyes
Homma R, Baker BJ, Jin L, Garaschuk O, Konnerth A, Cohen LB, Bleau CX, Canepari M, Djurisic M, Zecevic D. Wide-Field and Two-Photon Imaging of Brain Activity with Voltage and Calcium-Sensitive Dyes. Methods In Molecular Biology 2009, 489: 43-79. PMID: 18839087, DOI: 10.1007/978-1-59745-543-5_3.Peer-Reviewed Original ResearchConceptsCalcium-sensitive dyeOlfactory bulb glomeruliCell typesBrain activityIndividual cell typesOlfactory receptor neuronsNerve terminalsSynaptic activityVoltage-sensitive dyeSpike activityTwo-photon imagingVivo preparationMammalian brainReceptor neuronsIndividual neuronsIon-sensitive dyesNeuronsTwo-photon microscopyBrainMembrane potentialLow sensitivitySensitive dyeNoseOutput spike trainsSpike trains
2005
Imaging Brain Activity With Voltage- and Calcium-Sensitive Dyes
Baker BJ, Kosmidis EK, Vucinic D, Falk CX, Cohen LB, Djurisic M, Zecevic D. Imaging Brain Activity With Voltage- and Calcium-Sensitive Dyes. Cellular And Molecular Neurobiology 2005, 25: 245-282. PMID: 16050036, DOI: 10.1007/s10571-005-3059-6.Peer-Reviewed Original ResearchConceptsVoltage-sensitive dyeCalcium-sensitive dyeLight sourceDark noiseVibrational noiseOptical recordingRandom emissionBrain activityFluorescent protein sensorOlfactory receptor neuronsNerve terminalsOlfactory bulbSpike activityNoise ratioCell bodiesReceptor neuronsPhotonsOpticsOptimal signalNeuronsIndividual cell typesKinds of noiseExternal sourcesVoltageCell types
1989
Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex
Zecevic D, Wu J, Cohen L, London J, Hopp H, Falk C. Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex. Journal Of Neuroscience 1989, 9: 3681-3689. PMID: 2795148, PMCID: PMC6569909, DOI: 10.1523/jneurosci.09-10-03681.1989.Peer-Reviewed Original ResearchOptical Measurement of Action Potential Activity in Invertebrate Ganglia
Cohen L, Hopp H, Wu J, Xiao C, London J, Zecevic D. Optical Measurement of Action Potential Activity in Invertebrate Ganglia. Annual Review Of Physiology 1989, 51: 527-541. PMID: 2653195, DOI: 10.1146/annurev.ph.51.030189.002523.Peer-Reviewed Original ResearchConceptsAplysia abdominal ganglionGill withdrawal reflexBuccal gangliaAbdominal ganglionAction potential activitySynaptic potentialsGill withdrawalSpike activityGangliaNeuronal basisNeuronsInvertebrate gangliaBehaving animalsReflexNetwork of cellsPotential activityFeedingOptical measurementsActivity