Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin
Miron E, Oldenkamp R, Brown JM, Pinto DMS, Xu CS, Faria AR, Shaban HA, Rhodes JDP, Innocent C, de Ornellas S, Hess HF, Buckle V, Schermelleh L. Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin. Science Advances 2020, 6: eaba8811. PMID: 32967822, PMCID: PMC7531892, DOI: 10.1126/sciadv.aba8811.Peer-Reviewed Original ResearchChromatin domainsThree-dimensional chromatin organizationFunctional nuclear organizationMammalian genome functionActive histone modificationsSingle-cell levelInterchromatin compartmentGenome functionChromatin organizationGenome organizationRepressive modificationsHistone modificationsNuclear organizationEuchromatic regionsSomatic cellsCohesinChromatinFunctional modulesKey roleNucleosomesDomainRNACompartmentsModificationCells