2000
The Na-K-Cl Cotransporter of Secretory Epithelia
Haas M, Forbush B. The Na-K-Cl Cotransporter of Secretory Epithelia. Annual Review Of Physiology 2000, 62: 515-534. PMID: 10845101, DOI: 10.1146/annurev.physiol.62.1.515.Peer-Reviewed Original ResearchConceptsNa-K-ClNa-K-Cl cotransporterRegulation of NKCC1Secretory epitheliaNa-K-Cl cotransporter isoformsK-Cl cotransporter isoformsApical Cl- channelsNa-Cl cotransporterNon-epithelial cellsNKCC1 regulationCl- channelsBasolateral membraneCotransporter proteinFluid secretionNKCC isoformsNKCC1Ascending limbHenle's loopEpithelial cellsMacula densaIon transport proteinsTransport NaEpitheliaCotransporterCell volume
1998
The Na-K-Cl Cotransporters
Haas M, Forbush B. The Na-K-Cl Cotransporters. Journal Of Bioenergetics And Biomembranes 1998, 30: 161-172. PMID: 9672238, DOI: 10.1023/a:1020521308985.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterNa-K-ClNa-K-Cl cotransport activityNa-K-Cl cotransporter isoformsCotransport activitySecretory epitheliaApical Cl- channelsHypokalemic metabolic alkalosisCation-chloride cotransportersNKCC2 geneCl- channelsBartter's syndromeVolume depletionBasolateral membraneCotransporter proteinApical membraneSalt wastingMetabolic alkalosisSecreting epitheliaNonepithelial cellsAscending limbHenle's loopK-ClCotransporterEpithelial cells
1994
The molecular basis of chloride transport in shark rectal gland.
Riordan J, Forbush B, Hanrahan J. The molecular basis of chloride transport in shark rectal gland. Journal Of Experimental Biology 1994, 196: 405-418. PMID: 7529818, DOI: 10.1242/jeb.196.1.405.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological Transport, ActiveCarrier ProteinsChloride ChannelsChloridesCystic Fibrosis Transmembrane Conductance RegulatorEpitheliumHomeostasisHumansMembrane ProteinsModels, BiologicalPotassium ChannelsProtein Structure, SecondarySalt GlandSecond Messenger SystemsSharksSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseConceptsApical Cl- channelsCl- channelsProtein kinase ACl- secretionBasolateral transport proteinsTransepithelial Cl- secretionNa+/K(+)-ATPase pumpIntracellular chloride concentrationStimulation of secretionActive Na+ extrusionBasolateral cotransporterShark rectal glandNa+/K+/2Cl- cotransporterCl- movementK+ channelsK+ exitNa+/K(+)-ATPaseApical componentParacellular flowPrimary stimulationEpithelial cellsExcellent experimental modelCotransporterCFTRRectal gland of elasmobranchs
1992
Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules
Lytle C, Forbush B. Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules. American Journal Of Physiology 1992, 262: c1009-c1017. PMID: 1314482, DOI: 10.1152/ajpcell.1992.262.4.c1009.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterNa-K-ClShark rectal glandInhibitor of Na-K-Cl cotransportApical Cl- channelsCell shrinkageEffects of secretagoguesOsmotically induced changesSensitivity to cAMPCl- channelsExtracellular sodiumIsolated tubulesCotransporterHormonal modulationSecretory stimuliSignal transduction pathwaysSecretagoguesRectal glandTubulesRectal gland secretionHypertonicityCell volumeTransduction pathwaysGlandCells