2018
Role of the mechanosensitive ion channel Piezo1 in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Chebib F, Beyder A, Wang X, Alcaino C, Ehrlich B, Torres V. Role of the mechanosensitive ion channel Piezo1 in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The FASEB Journal 2018, 32: 868.2-868.2. DOI: 10.1096/fasebj.2018.32.1_supplement.868.2.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseCalcium entryCyclic AMPMIMCD3 cellsCytoplasmic calciumFluid shear stressWild-type miceDominant polycystic kidney diseaseRenal cystogenesisFull-text articlesNon-selective cation channelsPolycystic kidney diseaseKidney diseaseExperimental Biology 2018 MeetingIntracellular calciumType miceVivo effectsPathogenic mechanismsCystic epitheliumLive-cell imagingMechanosensitive ion channelsSecretory phenotypeATP releaseMechanosensitive ion channel Piezo1Cation channels
1991
Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum
Bezprozvanny L, Watras J, Ehrlich B. Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 1991, 351: 751-754. PMID: 1648178, DOI: 10.1038/351751a0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCell MembraneCerebellumCytoplasmDogsEndoplasmic ReticulumFeedbackInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingLipid BilayersReceptors, Cell SurfaceReceptors, CholinergicReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelConceptsCalcium-gated channelsRyanodine receptor/channelEndoplasmic reticulum vesiclesLigand sensitivityEndoplasmic reticulumReceptor/channelCalcium-activated channelChannel typesSame cellsIntracellular calcium regulationCalcium regulationPlanar bilayersCytoplasmic calciumIntracellular storesOpen probabilityCanine cerebellumComplex patternsDifferent responsesAdenine nucleotidesRelease of calciumFunctional propertiesRuthenium redMaximum activityInsP3Cells