2014
MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR
Zhang L, Bartley CM, Gong X, Hsieh LS, Lin TV, Feliciano DM, Bordey A. MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR. Neuron 2014, 84: 78-91. PMID: 25277454, PMCID: PMC4185153, DOI: 10.1016/j.neuron.2014.09.009.Peer-Reviewed Original ResearchConceptsDendritic complexityFLNA overexpressionDendritic abnormalitiesFLNA expressionDendritic patterningComplex dendritic arborsWild-type neuronsFilamin ADendritic arborsERK1/2-dependent mannerDendritic defectsNeurological defectsMEK-ERK1/2NeuronsMTOR activityNeurodevelopmental disordersNeurodevelopmental diseasesProtein filamin AAbnormalitiesMTOROverexpression
2008
Tonic activation of GLUK5 kainate receptors decreases neuroblast migration in whole‐mounts of the subventricular zone
Platel J, Heintz T, Young S, Gordon V, Bordey A. Tonic activation of GLUK5 kainate receptors decreases neuroblast migration in whole‐mounts of the subventricular zone. The Journal Of Physiology 2008, 586: 3783-3793. PMID: 18565997, PMCID: PMC2538932, DOI: 10.1113/jphysiol.2008.155879.Peer-Reviewed Original ResearchConceptsKainate receptorsSVZ neuroblastsLateral ventricleSubventricular zoneNeuroblast migrationAcute slicesMetabotropic glutamate receptor subtype 5AMPA/kainate receptorsMGluR5 antagonist MPEPPermeable kainate receptorsReceptor antagonist bicucullineActivation of mGluR5Postnatal day 20Postnatal subventricular zoneDCX promoterAntagonist MPEPWhole-mount preparationsAntagonist bicucullineMGluR5 activationCell aspiratesReceptor antagonistMouse slicesTonic activationSubtype 5Immunopositive cellsControl of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain
Platel J, Dave KA, Bordey A. Control of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain. The Journal Of Physiology 2008, 586: 3739-3743. PMID: 18467361, PMCID: PMC2538924, DOI: 10.1113/jphysiol.2008.155325.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNeuroblast productionGlutamate receptorsStem cellsSteady-state levelsAdult-born neuronsNovel epigenetic controlNeural stem cellsImmature neuronsAdult neurogenesisNeurotransmitter GABAOlfactory bulbPostnatal forebrainNeuron productionNew steady-state levelStem cell proliferationHigh-affinity uptake systemCalcium elevationNeurotransmitter releaseEpigenetic controlExtracellular concentrationGlutamate signalsGABANegative feedback controlNeuroblast numbersIntercellular signaling
1998
Properties of human glial cells associated with epileptic seizure foci
Bordey A, Sontheimer H. Properties of human glial cells associated with epileptic seizure foci. Epilepsy Research 1998, 32: 286-303. PMID: 9761328, DOI: 10.1016/s0920-1211(98)00059-x.Peer-Reviewed Original ResearchConceptsSeizure focusGlial cellsMesio-temporal lobe epilepsyWhole-cell patch-clamp recordingsLucifer YellowControl rat hippocampusPathophysiology of seizuresSlow action potentialsCurrent-clamp studiesGFAP-positive astrocytesEpileptic seizure fociPatch-clamp recordingsHuman glial cellsLobe epilepsyAcute slicesRat hippocampusEpilepsy patientsClamp studiesRat astrocytesAstrocytesIntermediate filaments GFAPNormal astrocytesAction potentialsPhysiological propertiesBranched processesExpression of voltage-activated chloride currents in acute slices of human gliomas
Ullrich N, Bordey A, Gillespie GY, Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 1998, 83: 1161-1173. PMID: 9502255, DOI: 10.1016/s0306-4522(97)00456-9.Peer-Reviewed Original ResearchConceptsAcute slicesChloride currentsGlioma cellsGrade tumorsGlial cellsPatient biopsiesWhole-cell patch-clamp recordingsChloride channelsHost glial cellsImplanted glioma cellsPathological tumor gradeLow-grade tumorsHigh-grade tumorsPatch-clamp recordingsSpecific Cl- channelsNormal glial cellsAstrocyte-like cellsShort-term cultureTumor gradePathological gradeSCID miceVoltage-activated sodiumIntracranial injectionPotassium currentExperimental tumors