2012
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornAstrocytesCalcium SignalingCapillariesCerebral VentriclesCerebrovascular CirculationElectric StimulationElectroporationFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedLaser-Doppler FlowmetryMaleMiceMuscle TonusMuscle, Smooth, VascularNeural Stem CellsPericytesVasoconstrictionVasodilationConceptsNeural progenitor cellsSubventricular zoneB cellsBlood flowSVZ cellsPurinergic receptorsPostnatal subventricular zoneVascular responsesCapillary constrictionTransgenic miceElectrical stimulationCalcium increaseBlood flow increasesLaser Doppler flowmetryCapillary blood flowAstrocyte-like cellsReceptor agonist UTPNeonatal electroporationNeurometabolic couplingIntraventricular injectionVasodilating factorsAcute slicesYoung miceDoppler flowmetryHemodynamic response
2009
Activation of adenosine A2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells
Genzen JR, Yang D, Ravid K, Bordey A. Activation of adenosine A2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells. Fluids And Barriers Of The CNS 2009, 6: 15. PMID: 19922651, PMCID: PMC2791093, DOI: 10.1186/1743-8454-6-15.Peer-Reviewed Original ResearchEpendymal cellsCiliary beat frequencyPurinergic receptorsCerebrospinal fluidA2B receptor activationReceptor activationP2X7-/- micePurinergic receptor subtypesAdenosine A2B receptorAdenosine receptor agonistsMetabolic breakdown productsCalcium imaging experimentsCerebrospinal fluid dynamicsA2B expressionFlow of CSFBrain parenchymaReceptor agonistPurinergic agentsReceptor subtypesAirway epitheliumFluid balancePharmacological approachesVentricular systemKnockout miceA2B receptorsEpendymal cells along the lateral ventricle express functional P2X7 receptors
Genzen JR, Platel JC, Rubio ME, Bordey A. Ependymal cells along the lateral ventricle express functional P2X7 receptors. Purinergic Signalling 2009, 5: 299-307. PMID: 19274488, PMCID: PMC2717311, DOI: 10.1007/s11302-009-9143-5.Peer-Reviewed Original ResearchP2X7 receptorEpendymal cellsSubventricular zoneWhole-cell patch-clamp recordingsCentral nervous system injuryFunctional P2X7 receptorsFunctional purinergic receptorsNervous system injuryPatch-clamp recordingsMouse subventricular zoneSVZ neurogenic nicheNeural progenitor responseAbsence of responseSystem injuryCerebral ventricleProgenitor responseLateral ventricleNeurogenic nichePurinergic receptorsClamp recordingsExtracellular adenosineReceptorsCellular damageWidespread expressionInflammation