MicroRNA miR‐137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb‐1
Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M, Teng Z, Luo Y, Peng J, Bordey A, Jin P, Zhao X. MicroRNA miR‐137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb‐1. Stem Cells 2010, 28: 1060-1070. PMID: 20506192, PMCID: PMC3140955, DOI: 10.1002/stem.431.Peer-Reviewed Original ResearchConceptsNeuronal maturationMiR-137Dendritic morphogenesisSpine developmentNovel miRNA-mediated mechanismCultured primary neuronsMiR-137 overexpressionConserved target sitesMiR-137 targetsBrain-enriched microRNAYoung neuronsMicroRNA miR-137Phenotypic maturationPrimary neuronsAxonal growthMiRNA-mediated mechanismMIB1Mind bomb-1NeuronsMessenger RNAMaturationOpposite effectOverexpressionMicroRNAsNeurodevelopment