2004
Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis
Bordey A, Spencer DD. Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis. Epilepsy Research 2004, 59: 107-122. PMID: 15246115, DOI: 10.1016/j.eplepsyres.2004.04.004.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyGlial cellsCA1 regionHilar astrocytesPutative astrocytesIntractable temporal lobe epilepsySclerotic human hippocampusTemporal lobe sclerosisNon-sclerotic hippocampiPatch-clamp recordingsIntercellular couplingSuch patientsEpileptic hippocampusLobe epilepsyCell-attached patchesPatient groupElectrophysiological alterationsDentate gyrusEpileptic humansChannel expressionAstrocytesElectrophysiological propertiesHippocampusTumor casesHuman hippocampus
2001
Electrophysiological Characteristics of Reactive Astrocytes in Experimental Cortical Dysplasia
Bordey A, Lyons SA, Hablitz JJ, Sontheimer H. Electrophysiological Characteristics of Reactive Astrocytes in Experimental Cortical Dysplasia. Journal Of Neurophysiology 2001, 85: 1719-1731. PMID: 11287494, DOI: 10.1152/jn.2001.85.4.1719.Peer-Reviewed Original ResearchConceptsGap junction couplingReactive gliosisFreeze lesionGlial fibrillary acidic protein immunoreactivityWhole-cell patch-clamp recordingsCell patch-clamp recordingsExperimental cortical dysplasiaCortical layers IPatch-clamp recordingsPostnatal day 16Reduced gap junction couplingNormal neuronal functionDysplastic neocortexP24 ratsDysplastic cortexReactive astrocytesCortical dysplasiaNeuronal dysfunctionProtein immunoreactivityElectrophysiological characteristicsAstrocytesChannel expressionNeuronal functionMicrosulcusLayer I
2000
Ion channel expression by astrocytes in situ: Comparison of different CNS regions
Bordey A, Sontheimer H. Ion channel expression by astrocytes in situ: Comparison of different CNS regions. Glia 2000, 30: 27-38. PMID: 10696142, DOI: 10.1002/(sici)1098-1136(200003)30:1<27::aid-glia4>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsBergmann glial cellsIon channel complementGlial cellsIon channel expressionDifferent CNS regionsCNS regionsChannel expressionPercentage of astrocytesTransient A-typeCerebellar Bergmann glial cellsChannel complementPatch-clamp recordingsVoltage-activated currentsPostnatal day 17Whole-cell currentsIon channelsVoltage-gated ion channelsBrain slicesRat astrocytesAstrocytesDay 17Low input resistanceInput resistanceCNSInitial recording
1997
Postnatal Development of Ionic Currents in Rat Hippocampal Astrocytes In Situ
Bordey A, Sontheimer H. Postnatal Development of Ionic Currents in Rat Hippocampal Astrocytes In Situ. Journal Of Neurophysiology 1997, 78: 461-477. PMID: 9242294, DOI: 10.1152/jn.1997.78.1.461.Peer-Reviewed Original ResearchConceptsHippocampal astrocytesPostnatal developmentCurrent sensitiveGlial cellsWhole-cell patch-clamp recordingsCell patch-clamp recordingsVoltage-activated sodium currentsGlial fibrillary acidic proteinRat hippocampal slicesRat hippocampal astrocytesFibrillary acidic proteinPatch-clamp recordingsOutward potassium currentEarly postnatal developmentIon channel expressionPercentage of cellsSteady-state activationStrong inward rectificationStratum radiatumHippocampal slicesCA1 regionDevelopmental changesPotassium currentChannel expressionEmbryonic rats