2020
Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalDiabetic FootHumansInduced Pluripotent Stem CellsMaleMesenchymal Stem CellsMiceMice, NudeMyocytes, Smooth MuscleNeovascularization, PhysiologicWound HealingConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2018
Molecular identity of arteries, veins, and lymphatics
Wolf K, Hu H, Isaji T, Dardik A. Molecular identity of arteries, veins, and lymphatics. Journal Of Vascular Surgery 2018, 69: 253-262. PMID: 30154011, PMCID: PMC6309638, DOI: 10.1016/j.jvs.2018.06.195.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsArteriesBiomarkersCOUP Transcription Factor IIEphrin-B2Gene Expression Regulation, DevelopmentalGestational AgeHomeodomain ProteinsHumansIntracellular Signaling Peptides and ProteinsLymphangiogenesisLymphatic VesselsMembrane ProteinsNeovascularization, PhysiologicReceptor, EphB4Receptors, NotchSignal TransductionTumor Suppressor ProteinsVascular Endothelial Growth Factor Receptor-2Vascular Surgical ProceduresVeinsConceptsMolecular identityEphrin-B2 expressionVessel identityVascular identityMolecular determinantsVenous identityArterial-venous identityCritical molecular determinantsEph-B4Specific molecular markersEmbryonic developmentMolecular mechanismsMolecular markersArterial identityUndifferentiated cellsEphrin-B2Adult vesselsDifferent functionsPostsurgical environmentExpressionEndothelial cellsStructural differencesCellsNew therapeutic approachesLymphatic vessels