2020
TGFβ (Transforming Growth Factor-Beta)–Activated Kinase 1 Regulates Arteriovenous Fistula Maturation
Hu H, Lee SR, Bai H, Guo J, Hashimoto T, Isaji T, Guo X, Wang T, Wolf K, Liu S, Ono S, Yatsula B, Dardik A. TGFβ (Transforming Growth Factor-Beta)–Activated Kinase 1 Regulates Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: e203-e213. PMID: 32460580, PMCID: PMC7316601, DOI: 10.1161/atvbaha.119.313848.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaArteriovenous Shunt, SurgicalCells, CulturedCollagen Type IEndothelial CellsFibronectinsHumansJNK Mitogen-Activated Protein KinasesMaleMAP Kinase Kinase KinasesMechanotransduction, CellularMice, Inbred C57BLP38 Mitogen-Activated Protein KinasesPhosphorylationStress, MechanicalVascular PatencyVascular RemodelingVena Cava, InferiorConceptsArteriovenous fistulaAVF maturationNoncanonical TGFβSuccessful AVF maturationArteriovenous fistula maturationNovel therapeutic approachesTAK1 functionsFistula maturationHemodialysis accessDeposition of ECMLuminal diameterMouse endothelial cellsMaturation failureTherapeutic approachesLumen dilationControl veinsWall thickeningAVF modelOptimal conduitArterial magnitudesEndothelial cellsTAK1 phosphorylationCollagen 1Growth factorLaminar shear stress
2011
Surgical Treatment of Vascular Occlusive Disease
Feigel A, Dardik A. Surgical Treatment of Vascular Occlusive Disease. 2011, 663-672. DOI: 10.1007/978-1-4419-6999-6_54.ChaptersPeripheral arterial diseaseBlood flowElderly patientsIntimal thickeningLower extremitiesElderly populationImpact of PADSymptoms of PADTreatment of PADVascular occlusive diseaseProgressive intimal thickeningDistal blood flowSpectrum of diseaseArterial blood flowAtherosclerotic intimal thickeningDistal emboliOcclusive diseaseCoronary diseaseSurgical treatmentArterial diseaseCarotid diseaseEndovascular treatmentVisceral circulationAbdominal visceraLuminal diameter