2024
Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, PMCID: PMC11380968, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2012
Neointimal Hyperplasia: Basic Considerations
Model L, Dardik A. Neointimal Hyperplasia: Basic Considerations. 2012, 178-196. DOI: 10.1002/9781118481370.ch10.ChaptersSmooth muscle cell proliferationMuscle cell proliferationNeointimal hyperplasiaIII trialsBypass graft failureCell proliferationVein graft adaptationVein graft restenosisExtracellular matrix depositionGraft failureVein graftsVascular surgeonsVascular surgeryGraft restenosisGraft adaptationNew molecular mechanismHyperplasiaTrialsRestenosisMatrix depositionBody responseArterial environmentMolecular mechanismsDisappointing failuresProliferation