2024
Representation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years
Kostiuk V, Thaxton C, Loh S, Cardella J, Dardik A, Tonnessen B. Representation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years. JVS-Vascular Insights 2024, 2: 100077. DOI: 10.1016/j.jvsvi.2024.100077.Peer-Reviewed Original ResearchClinical trialsFemale vascular surgeonsVascular surgeonsMethods Clinical trialsArtery diseaseClinical trial leadershipSite principal investigatorsVascular conditionsAbdominal aortic aneurysmSurgeon-investigatorInvestigator-led trialsCarotid artery diseasePeripheral arterial diseaseCarotid diseaseProportion of womenVenous thrombectomyBoard certificationAortic aneurysmPercentage of womenIndustry-sponsored trialsTrial leadershipHemodialysis accessSubgroup analysisVascular surgerySurgeons
2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Bai H, Sadaghianloo N, Gorecka J, Liu S, Ono S, Ramachandra AB, Bonnet S, Mazure NM, Declemy S, Humphrey JD, Dardik A. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Science Translational Medicine 2020, 12 PMID: 32817365, PMCID: PMC7705473, DOI: 10.1126/scitranslmed.aax7613.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaHemodialysis accessNeointimal hyperplasiaEndothelial nitric oxide synthaseDurable surgical optionUremic male ratsRadial-cephalic arteriovenous fistulaKruppel-like factor 2Nitric oxide synthasePeak systolic velocityLong-term patencyReintervention rateSecondary patencyImproved hemodynamicsFemale patientsReimplantation techniqueSurgical optionsSystolic velocityMale ratsOxide synthaseFistula modelPatencyHemodynamicsDifferent hemodynamicsFemale animalsTGFβ (Transforming Growth Factor-Beta)–Activated Kinase 1 Regulates Arteriovenous Fistula Maturation
Hu H, Lee SR, Bai H, Guo J, Hashimoto T, Isaji T, Guo X, Wang T, Wolf K, Liu S, Ono S, Yatsula B, Dardik A. TGFβ (Transforming Growth Factor-Beta)–Activated Kinase 1 Regulates Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: e203-e213. PMID: 32460580, PMCID: PMC7316601, DOI: 10.1161/atvbaha.119.313848.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaArteriovenous Shunt, SurgicalCells, CulturedCollagen Type IEndothelial CellsFibronectinsHumansJNK Mitogen-Activated Protein KinasesMaleMAP Kinase Kinase KinasesMechanotransduction, CellularMice, Inbred C57BLP38 Mitogen-Activated Protein KinasesPhosphorylationStress, MechanicalVascular PatencyVascular RemodelingVena Cava, InferiorConceptsArteriovenous fistulaAVF maturationNoncanonical TGFβSuccessful AVF maturationArteriovenous fistula maturationNovel therapeutic approachesTAK1 functionsFistula maturationHemodialysis accessDeposition of ECMLuminal diameterMouse endothelial cellsMaturation failureTherapeutic approachesLumen dilationControl veinsWall thickeningAVF modelOptimal conduitArterial magnitudesEndothelial cellsTAK1 phosphorylationCollagen 1Growth factorLaminar shear stress
2016
3 Next generation ECM-based vascular biomaterials
Brownson K, Dardik A. 3 Next generation ECM-based vascular biomaterials. 2016, 19-40. DOI: 10.1016/b978-0-08-100166-0.00003-7.ChaptersVascular biomaterialsCarotid endarterectomySynthetic scaffold materialsLong-term strokeSuperior clinical outcomesPericardial patch closureMedical implantsPrimary arteriotomy closureScaffold materialsPatch closureClinical outcomesPseudoaneurysm formationSurgical closureArterial occlusionAutologous veinHemodialysis accessPericardial patchArteriotomy closureDeath riskPatient outcomesDiseased vesselsCardiovascular surgeryUmbilical veinLower riskVascular surgery today