2022
Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2020
Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice
Kudze T, Ono S, Fereydooni A, Gonzalez L, Isaji T, Hu H, Yatsula B, Taniguchi R, Koizumi J, Nishibe T, Dardik A. Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice. JVS Vascular Science 2020, 1: 42-56. PMID: 32754721, PMCID: PMC7402599, DOI: 10.1016/j.jvssci.2020.03.001.Peer-Reviewed Original ResearchInfrarenal inferior vena cavaArteriovenous fistulaFemale miceMale miceHuman AVF maturationAVF maturationAVF patencyVascular cell adhesion molecule-1Superior long-term outcomesEndothelial nitric oxide synthaseCell adhesion molecule-1Male C57BL/6 miceLong-term outcomesInferior vena cavaNitric oxide synthaseAdhesion molecule-1Krüppel-like factor 2Significant differencesSex-specific differential expressionMessenger RNAAVF remodelingAVF utilizationFistula utilizationAortocaval fistulaFistula patency
1991
Infrapopliteal prosthetic graft patency by use of the distal adjunctive arteriovenous fistula
Dardik H, Berry S, Dardik A, Wolodiger F, Pecoraro J, Ibrahim I, Kahn M, Sussman B. Infrapopliteal prosthetic graft patency by use of the distal adjunctive arteriovenous fistula. Journal Of Vascular Surgery 1991, 13: 685-691. PMID: 2027208, DOI: 10.1016/0741-5214(91)90354-w.Peer-Reviewed Original ResearchConceptsDistal arteriovenous fistulaArteriovenous fistulaPatent fistulaAdjunctive arteriovenous fistulaProsthetic graft patencyCumulative patency rateVascular reconstructive proceduresPeak systolic velocityCrural reconstructionsPostoperative arteriographyDistal anastomosisFistula patencyGraft patencyPatent graftsDuplex ultrasonographyProsthetic graftsAutologous veinDistal arteriesGraft flowGraft surveillancePatency ratesSystolic velocityDuplex sonographyTherapeutic resultsDistal vessels