Yi Di
Associate Research Scientist in PharmacologyCards
About
Research
Publications
2026
Baseline cellular state shapes the molecular impact of mutant <em>KRAS</em> alleles in reconstituted pancreatic cancer cells
Quiñones-Avilés Y, Salovska B, Markham CS, Di Y, Turk BE, Liu Y, Muzumdar MD. Baseline cellular state shapes the molecular impact of mutant KRAS alleles in reconstituted pancreatic cancer cells. Molecular Omics 2026, aaiag022. DOI: 10.1093/molecular-omics/aaiag022.Peer-Reviewed Original ResearchBaseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells.
Quiñones-Avilés Y, Salovska B, Markham CS, Di Y, Turk BE, Liu Y, Muzumdar MD. Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells. BioRxiv 2026 PMID: 41959224, DOI: 10.64898/2026.03.10.710185.Peer-Reviewed Original Research
2025
Divergent proteome tolerance against gain and loss of chromosome arms
Di Y, Li W, Castellano J, Jin W, Modi J, Salovska B, Khosroabadi D, Hu W, Taylor A, Liu Y. Divergent proteome tolerance against gain and loss of chromosome arms. Molecular Cell 2025, 85: 4268-4278.e6. PMID: 41270725, PMCID: PMC12991381, DOI: 10.1016/j.molcel.2025.10.023.Peer-Reviewed Original ResearchThis study investigates how cells tolerate chromosome arm aneuploidy, showing distinct mechanisms where protein degradation compensates for gains, while synthesis upregulates proteins in losses to maintain balance.
2024
PTMoreR-enabled cross-species PTM mapping and comparative phosphoproteomics across mammals
Wang S, Di Y, Yang Y, Salovska B, Li W, Hu L, Yin J, Shao W, Zhou D, Cheng J, Liu D, Yang H, Liu Y. PTMoreR-enabled cross-species PTM mapping and comparative phosphoproteomics across mammals. Cell Reports Methods 2024, 4: 100859. PMID: 39255793, PMCID: PMC11440062, DOI: 10.1016/j.crmeth.2024.100859.Peer-Reviewed Original Research
2023
An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
Zhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk B, Sessa W, Liu Y. An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells. Nature Communications 2023, 14: 3803. PMID: 37365174, PMCID: PMC10293293, DOI: 10.1038/s41467-023-39514-1.Peer-Reviewed Original Research
2021
Data-independent acquisition-based proteome and phosphoproteome profiling across six melanoma cell lines reveals determinants of proteotypes
Gao E, Li W, Wu C, Shao W, Di Y, Liu Y. Data-independent acquisition-based proteome and phosphoproteome profiling across six melanoma cell lines reveals determinants of proteotypes. Molecular Omics 2021, 17: 413-425. PMID: 33728422, PMCID: PMC8205956, DOI: 10.1039/d0mo00188k.Peer-Reviewed Original ResearchBoxCarmax: A High-Selectivity Data-Independent Acquisition Mass Spectrometry Method for the Analysis of Protein Turnover and Complex Samples
Salovska B, Li W, Di Y, Liu Y. BoxCarmax: A High-Selectivity Data-Independent Acquisition Mass Spectrometry Method for the Analysis of Protein Turnover and Complex Samples. Analytical Chemistry 2021, 93: 3103-3111. PMID: 33533601, PMCID: PMC8959401, DOI: 10.1021/acs.analchem.0c04293.Peer-Reviewed Original Research
2020
Global and Site-Specific Effect of Phosphorylation on Protein Turnover
Wu C, Ba Q, Lu D, Li W, Salovska B, Hou P, Mueller T, Rosenberger G, Gao E, Di Y, Zhou H, Fornasiero EF, Liu Y. Global and Site-Specific Effect of Phosphorylation on Protein Turnover. Developmental Cell 2020, 56: 111-124.e6. PMID: 33238149, PMCID: PMC7855865, DOI: 10.1016/j.devcel.2020.10.025.Peer-Reviewed Original Research
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