Cat McCann, PhD

they/them/theirs

Research Associate 2

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Contact Info

cat.mccann@yale.edu

About

Titles

Research Associate 2

Departments & Organizations

Pharmacology

Education & Training

PhD: Johns Hopkins University School of Medicine, Cellular and Molecular Physiology (2021)

BSc: Worcester Polytechnic Institute, Biochemistry (2013)

Research

Research at a Glance

Publications Timeline

A big-picture view of Cat McCann's research output by year.

7Publications

Publications

2022

Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner.
McCann CJ, Hasan NM, Padilla-Benavides T, Roy S, Lutsenko S. Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner. Front Mol Biosci 2022, 9: 1067490. PMID: 36545508, DOI: 10.3389/fmolb.2022.1067490.
Peer-Reviewed Original Research
The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro.
McCann C, Quinteros M, Adelugba I, Morgada MN, Castelblanco AR, Davis EJ, Lanzirotti A, Hainer SJ, Vila AJ, Navea JG, Padilla-Benavides T. The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro. Front Mol Biosci 2022, 9: 1037941. PMID: 36438658, DOI: 10.3389/fmolb.2022.1037941.
Peer-Reviewed Original Research
ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.
Olea-Flores M, Kan J, Carlson A, Syed SA, McCann C, Mondal V, Szady C, Ricker HM, McQueen A, Navea JG, Caromile LA, Padilla-Benavides T. ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype. Front Cell Dev Biol 2022, 10: 895433. PMID: 35898402, DOI: 10.3389/fcell.2022.895433.
Peer-Reviewed Original Research

2020

Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties.
Roy S, McCann CJ, Ralle M, Ray K, Ray J, Lutsenko S, Jayakanthan S. Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties. Sci Rep 2020, 10: 13487. PMID: 32778786, DOI: 10.1038/s41598-020-70366-7.
Peer-Reviewed Original Research

2019

Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.
McCann CJ, Jayakanthan S, Siotto M, Yang N, Osipova M, Squitti R, Lutsenko S. Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein. Metallomics 2019, 11: 1128-1139. PMID: 31070637, DOI: 10.1039/c9mt00057g.
Peer-Reviewed Original Research
Chapter 4 - Biochemical and Cellular Properties of ATP7B Variants
Samuel Jayakanthan, Courtney McCann, Svetlana Lutsenko
Chapters

2013

The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites.
Padilla-Benavides T, McCann CJ, Argüello JM. The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites. J Biol Chem 2013, 288: 69-78. PMID: 23184962, DOI: 10.1074/jbc.M112.420810.
Peer-Reviewed Original Research

Get In Touch

Contacts

cat.mccann@yale.edu

Locations

Sterling Hall of Medicine
Academic Office
333 Cedar Street, Wing B, Fl 2, Rm 208
New Haven, CT 06510
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Events

Apr 202524Thursday

12:00 PM1:00 PM
Everyone
Stephen Trent, PhD
Pharmacology Seminar Series
"Pushing the Envelope: Building and Maintaining the Gram-negative Outer Membrane"
Brady Memorial Laboratory
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May 20251Thursday

12:00 PM1:00 PM
Yale Only
Roland Dunbrack, Ph.D.
Pharmacology Seminar Series presents: "Structural Bioinformatics and AlphaFold Modeling of Protein Kinases and their Interactions"
Brady Memorial Laboratory
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May 20258Thursday

12:00 PM1:00 PM
Yale Only
Angela Gronenborn, Ph.D.
Pharmacology Seminar Series presents: "The Awesome Power of Fluorine NMR—From Drugs to Cells"
Brady Memorial Laboratory
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May 202522Thursday

4:00 PM5:00 PM
Everyone
Karen Vousden, PhD
Yale Pharmacology Department presents the Alan C. Sartorelli Lectureship - Dr. Karen Vousden
"Diet, Metabolism, and Cancer Progression"
The Anlyan Center
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Contact Info

Titles

Departments & Organizations

Education & Training

Research at a Glance

Publications Timeline

Publications

2022

Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner.

The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro.

ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.

2020

Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties.

2019

Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.

Chapter 4 - Biochemical and Cellular Properties of ATP7B Variants

2013

The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites.

Contacts

Locations

Sterling Hall of Medicine

Events

Pharmacology Seminar Series

Pharmacology Seminar Series presents: "Structural Bioinformatics and AlphaFold Modeling of Protein Kinases and their Interactions"

Pharmacology Seminar Series presents: "The Awesome Power of Fluorine NMR—From Drugs to Cells"

Yale Pharmacology Department presents the Alan C. Sartorelli Lectureship - Dr. Karen Vousden