2017
Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV
Aghourian M, Legault-Denis C, Soucy J, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard M. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV. Molecular Psychiatry 2017, 22: 1531-1538. PMID: 28894304, DOI: 10.1038/mp.2017.183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainCase-Control StudiesCholinergic AgentsCholinergic NeuronsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPiperidinesPositron-Emission TomographyPresynaptic TerminalsRadioactive TracersVesicular Acetylcholine Transport ProteinsConceptsMini-Mental State ExaminationStandardized uptake value ratioAlzheimer's diseaseCortical areasPresynaptic cholinergic nerve terminalsAmyloid-beta tracerNumerous cortical areasCognitive scalesCholinergic nerve terminalsUptake value ratioVesicular acetylcholine transporterMultiple cortical areasNew PET radiotracersVoxel-wise t-testsCholinergic denervationCholinergic terminalsCholinergic degenerationControl subjectsAD patientsCholinergic lossNerve terminalsAD groupHealthy subjectsAcetylcholine transporterAD subjects
2010
Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET
la Fougère C, Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper H, Reader A, Evans A, Thiel A. Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET. NeuroImage 2010, 56: 951-960. PMID: 21073964, DOI: 10.1016/j.neuroimage.2010.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBrain MappingCerebral CortexData Interpretation, StatisticalFemaleFlumazenilGABA ModulatorsHumansImage Processing, Computer-AssistedIndividualityIsotope LabelingMagnetic Resonance ImagingMaleMiddle AgedNeuronsPositron-Emission TomographyRadiopharmaceuticalsReceptors, GABARegression AnalysisConceptsNeuronal densityCortical thicknessAxo-dendritic synapsesSensory-motor cortexHuman brain areasDifferent cytoarchitectonic areasFlumazenil PETMotor cortexApparent cortical thicknessCortical thickness mapsHealthy subjectsBrain areasMorphometry studyCytoarchitectonic areasCortical morphologyCortical regionsCortical distributionVivo studiesFMZReceptor complexPartial volume correctionCytoarchitectonicsSensitive toolDifferential relationshipsSubset
2006
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder
Mazza S, Soucy J, Gravel P, Michaud M, Postuma R, Massicotte-Marquez J, Decary A, Montplaisir J. Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. Neurology 2006, 67: 1618-1622. PMID: 17101893, DOI: 10.1212/01.wnl.0000242879.39415.49.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrainBrain StemCerebral ArteriesCerebral CortexCerebrovascular CirculationCorpus StriatumCysteineFemaleHumansMaleMiddle AgedNeurodegenerative DiseasesOrganotechnetium CompoundsParkinson DiseasePolysomnographyPredictive Value of TestsPrognosisREM Sleep Behavior DisorderTomography, Emission-Computed, Single-PhotonConceptsREM behavior disorderBehavior disorderCerebral blood flow evaluationREM sleep behavior disorderIdiopathic REM behavior disorderSleep behavior disorderBrain perfusion changesRegional cerebral perfusionBlood flow evaluationAge-matched controlsTemporo-parietal cortexCerebral perfusionDecreased perfusionPerfusion changesPerfusional abnormalitiesRight hippocampusParkinson's diseasePatientsMetabolic profilePerfusionDisordersAbnormalitiesCortexFlow evaluationBrainstem