2017
Posterior dopamine D2/3 receptors and brain network functional connectivity
Nagano‐Saito A, Lissemore J, Gravel P, Leyton M, Carbonell F, Benkelfat C. Posterior dopamine D2/3 receptors and brain network functional connectivity. Synapse 2017, 71 PMID: 28700819, DOI: 10.1002/syn.21993.Peer-Reviewed Original ResearchConceptsDefault mode networkNetwork functional connectivityFunctional connectivity strengthPositron emission tomographyFunctional connectivityPosterior portionReceptor distributionPosteromedial cortexResting-state functional magnetic resonance imagingConnectivity strengthBrain network functional connectivityPosterior default mode networkMode networkDopamine D2/3 receptorsDopamine receptor distributionResting-state connectivityBrain networksFunctional magnetic resonance imagingMagnetic resonance imagingMultiple brain networksFallypride bindingDorsal attention networkMean BPBrain dopamineD2/3 receptors
2016
Cocaine cue–induced dopamine release in the human prefrontal cortex
Milella M, Fotros A, Gravel P, Casey K, Larcher K, Verhaeghe J, Cox S, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine cue–induced dopamine release in the human prefrontal cortex. Journal Of Psychiatry And Neuroscience 2016, 41: 322-330. PMID: 26900792, PMCID: PMC5008921, DOI: 10.1503/jpn.150207.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzamidesBrain MappingCocaineCocaine-Related DisordersCorpus StriatumCravingCuesDopamineDopamine D2 Receptor AntagonistsDopamine Uptake InhibitorsFemaleFluorine RadioisotopesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyPrefrontal CortexRadiopharmaceuticalsConceptsDA releaseMedial orbitofrontal cortexPrefrontal cortexDrug-related cuesDopamine releaseHuman prefrontal cortexOrbitofrontal cortexCortical DA releasePresence of autoreceptorsDA cell bodiesD2 receptor levelsD2/3 receptor availabilityCurrent cocaine dependencePositron emission tomographyCocaine use disorderDorsolateral prefrontal cortexSelf-reported cravingStriatal changesHigh-resolution positron emission tomographyReceptor levelsSeparate regulatory mechanismsStriatal regionsDA responseUse disordersReceptor availability
2013
Stress‐induced dopamine release in human medial prefrontal cortex—18F‐Fallypride/PET study in healthy volunteers
Nagano‐Saito A, Dagher A, Booij L, Gravel P, Welfeld K, Casey K, Leyton M, Benkelfat C. Stress‐induced dopamine release in human medial prefrontal cortex—18F‐Fallypride/PET study in healthy volunteers. Synapse 2013, 67: 821-830. PMID: 23939822, DOI: 10.1002/syn.21700.Peer-Reviewed Original ResearchConceptsStress-induced dopamine releaseDopamine releaseHeart ratePsychological stressorsMesocortical dopamine releaseHealthy young adultsSalivary cortisol levelsStress-induced increaseMedial prefrontal cortexPositron emission tomographyMesocortical dopamine systemStress-induced decreasePresent studyTissue compartmental modelMotor zoneHealthy volunteersRostal partDopamine systemCortisol levelsWhole brainBP NDDorsal partSeparate daysEmission tomographyPET studiesCocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants
Fotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants. Neuropsychopharmacology 2013, 38: 1780-1788. PMID: 23546387, PMCID: PMC3717549, DOI: 10.1038/npp.2013.77.Peer-Reviewed Original ResearchConceptsDA releaseDopamine releaseVisual analog scaleDrug cue exposureCocaine-dependent volunteersDrug-seeking behaviorCocaine-dependent participantsAnalog scaleDrug-related cuesLimbic networkAnimal studiesCocaine dependenceHippocampusCue exposureAmygdalaPreferential inductionBPND valuesPotent triggerStriatumDependent participantsCocaine cuesReward networkSubjective responsesNeutral cuesFirst evidence