2020
Neuroimaging of Obsessive-Compulsive Disorder: Insights into Serotonergic Mechanisms
Lissemore J, Booij L, Leyton M, Gravel P, Sookman D, Nordahl T, Benkelfat C. Neuroimaging of Obsessive-Compulsive Disorder: Insights into Serotonergic Mechanisms. 2020, 457-478. DOI: 10.1007/978-3-030-57231-0_13.Peer-Reviewed Original ResearchSelective serotonin reuptake inhibitorsObsessive-compulsive disorderSerotonin synthesis capacityPositron emission tomographyHealthy controlsPET studiesOCD patientsSerotonin reuptake inhibitorsMost PET studiesBorderline personality disorderCognitive behavior therapySymptom onsetSerotonergic mechanismsClinical benefitSerotonergic toneSerotonergic alterationsSynthesis capacityEmission tomographySuicide attemptsSerotonin transporterPersonality disorderBehavior therapyGroup differencesDisordersPatients
2018
Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline
Lissemore J, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl T, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C. Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. Translational Psychiatry 2018, 8: 82. PMID: 29666372, PMCID: PMC5904107, DOI: 10.1038/s41398-018-0128-4.Peer-Reviewed Original ResearchConceptsSerotonin synthesis capacitySelective serotonin reuptake inhibitorsCognitive behavioral therapyObsessive-compulsive disorderPartial respondersTreatment modalitiesMedication-free OCD patientsBehavioral therapyOCD patientsSerotonin reuptake inhibitorsWeeks of treatmentRegional tracer uptakePost-treatment changesPositron emission tomographySynthesis capacityClinical improvementSSRI treatmentReuptake inhibitorsSertraline treatmentSymptom improvementRaphe nucleusNeurochemical changesSerotonergic toneSymptom responseEffective treatment
2014
Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study
Booij L, Soucy J, Young S, Regoli M, Gravel P, Diksic M, Leyton M, Pihl R, Benkelfat C. Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study. Journal Of Neurochemistry 2014, 131: 634-644. PMID: 25041501, DOI: 10.1111/jnc.12826.Peer-Reviewed Original ResearchConceptsMDMA polydrug usersMDMA usePolydrug usersLong-term neurotoxic effectsBrain serotonin synthesisSerotonin synthesis capacityDistal brain regionsNeurotoxicity of MDMAPositron emission tomographySynthesis capacityTracer alphaSerotonin synthesisNeurotoxic effectsPre-frontal regionsTemporal areaBrain regionsEmission tomographyCompensatory mechanismsTryptophan studiesParietal regionsMethylenedioxymethamphetamine (MDMA) useLonger durationBrainstemMDMA usersOCD: Serotonergic Mechanisms
Lissemore J, Leyton M, Gravel P, Sookman D, Nordahl T, Benkelfat C. OCD: Serotonergic Mechanisms. 2014, 433-450. DOI: 10.1007/978-3-642-40384-2_17.Peer-Reviewed Original ResearchSelective serotonin reuptake inhibitorsCognitive behavioral therapyObsessive-compulsive disorderPositron emission tomographySerotonergic mechanismsSerotonin reuptake inhibitorsSerotonin synthesis capacitySymptomatic improvementSymptom improvementCortico-striatoHealthy controlsSerotonin synthesisThalamic loopNeurobiological effectsEmission tomographyBrain circuitsBehavioral therapyNeurotransmitter serotoninBehavioral interventionsOCD patientsOCD pathologyRecent studiesSynthesis capacityTreatmentPatients
2012
Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study
Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay R. Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study. European Neuropsychopharmacology 2012, 22: 419-423. PMID: 22257439, DOI: 10.1016/j.euroneuro.2011.11.002.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexOrbitofrontal cortexSerotonin neurotransmissionPerinatal adversityPositron emission tomography scanEarly postnatal stressorsLow birth weightEmission tomography scanBrain serotonin neurotransmissionBrain serotonin synthesisSerotonin synthesis capacityStudies reporting associationLongitudinal studyMental health problemsEffects of childhoodLife-long impactTracer alphaMaternal smokingPerinatal effectsBirth complicationsBirth weightRisk factorsTomography scanSerotonin pathwaySerotonin synthesis
2006
Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping
Sibon I, Strafella A, Gravel P, Ko J, Booij L, Soucy J, Leyton M, Diksic M, Benkelfat C. Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping. NeuroImage 2006, 34: 1658-1664. PMID: 17188517, DOI: 10.1016/j.neuroimage.2006.08.059.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationLeft dorsolateral prefrontal cortexAcute repetitive transcranial magnetic stimulationLeft occipital cortexHealthy volunteersLimbic areasMajor depressionHigh-frequency repetitive transcranial magnetic stimulationHz repetitive transcranial magnetic stimulationPrefrontal repetitive transcranial magnetic stimulationRight cingulate gyrusSerotonin synthesis capacityTranscranial magnetic stimulationAutonomic measuresLeft parahippocampal gyrusDorsolateral prefrontal cortexMechanism of actionRTMS sessionsBrain uptakeRandomized counterbalanced orderCingulate gyrusRight insulaOccipital cortexMagnetic stimulationParahippocampal gyrus