2018
Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline
Lissemore J, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl T, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C. Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. Translational Psychiatry 2018, 8: 82. PMID: 29666372, PMCID: PMC5904107, DOI: 10.1038/s41398-018-0128-4.Peer-Reviewed Original ResearchConceptsSerotonin synthesis capacitySelective serotonin reuptake inhibitorsCognitive behavioral therapyObsessive-compulsive disorderPartial respondersTreatment modalitiesMedication-free OCD patientsBehavioral therapyOCD patientsSerotonin reuptake inhibitorsWeeks of treatmentRegional tracer uptakePost-treatment changesPositron emission tomographySynthesis capacityClinical improvementSSRI treatmentReuptake inhibitorsSertraline treatmentSymptom improvementRaphe nucleusNeurochemical changesSerotonergic toneSymptom responseEffective treatment
2011
Brain Regionalα-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder
Berney A, Leyton M, Gravel P, Sibon I, Sookman D, Neto P, Diksic M, Nakai A, Pinard G, Todorov C, Okazawa H, Blier P, Nordahl T, Benkelfat C. Brain Regionalα-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder. JAMA Psychiatry 2011, 68: 732-741. PMID: 21383250, PMCID: PMC3677917, DOI: 10.1001/archgenpsychiatry.2011.16.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingObsessive-compulsive disorderMedication-free patientsHealthy controlsMcGill University Health CentreGlucose metabolic disturbancesAdults meeting criteriaMain outcome measuresUniversity Health CentrePositron emission tomographyDepartment of PsychiatryStatistical parametric mappingTemporal lobe activityMontreal Neurological InstituteSerotonergic componentReuptake inhibitorsSerotonin dysfunctionClinical efficacySerotonergic abnormalitiesMetabolic disturbancesPostsynaptic changesSymptomatic stateSerotonergic systemHealth centersOutcome measures