2018
Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline
Lissemore J, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl T, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C. Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. Translational Psychiatry 2018, 8: 82. PMID: 29666372, PMCID: PMC5904107, DOI: 10.1038/s41398-018-0128-4.Peer-Reviewed Original ResearchConceptsSerotonin synthesis capacitySelective serotonin reuptake inhibitorsCognitive behavioral therapyObsessive-compulsive disorderPartial respondersTreatment modalitiesMedication-free OCD patientsBehavioral therapyOCD patientsSerotonin reuptake inhibitorsWeeks of treatmentRegional tracer uptakePost-treatment changesPositron emission tomographySynthesis capacityClinical improvementSSRI treatmentReuptake inhibitorsSertraline treatmentSymptom improvementRaphe nucleusNeurochemical changesSerotonergic toneSymptom responseEffective treatment
2008
MicroPET imaging of 5-HT1A receptors in rat brain: a test–retest [18F]MPPF study
Aznavour N, Benkelfat C, Gravel P, Aliaga A, Rosa-Neto P, Bedell B, Zimmer L, Descarries L. MicroPET imaging of 5-HT1A receptors in rat brain: a test–retest [18F]MPPF study. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 36: 53. PMID: 18704404, DOI: 10.1007/s00259-008-0891-1.Peer-Reviewed Original ResearchConceptsPositron emission tomographyRaphe nucleusIsoflurane-anaesthetised ratsParaventricular hypothalamic nucleusMedial prefrontal cortexTest-retest variabilityNon-human primatesSimplified reference tissue modelReference tissue modelHypothalamic nucleiRaphe obscurusMagnetic resonance imaging dataBasolateral amygdaloidRat brainLarge brain regionsParaventricular hypothalamicBrain regionsEmission tomographyReceptor functionPrefrontal cortexMicroPET imagingBrain imagingRatsPotential of serotoninReceptors