2024
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model
Lagier D, Zeng C, Kaczka D, Zhu M, Grogg K, Gerard S, Reinhardt J, Ribeiro G, Rashid A, Winkler T, Vidal Melo M. Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model. Science Translational Medicine 2024, 16: eado1097. PMID: 39141699, DOI: 10.1126/scitranslmed.ado1097.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureMechanical ventilationFour-dimensional computed tomographyParenchymal strainsVentilator-induced lung injuryAcute respiratory distress syndromeRespiratory system driving pressureManagement of mechanical ventilationPositive end-expiratory pressure valuesRespiratory distress syndromeTidal overdistensionEnd-expiratory pressureAssociated with mortalityPulmonary complicationsLung biomechanicsLung massDistress syndromeClinical outcomesLung injuryComputed tomographyClinical managementGeneral anesthesiaLung collapseDriving pressureLung
2023
Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury
Zeng C, Zhu M, Motta-Ribeiro G, Lagier D, Hinoshita T, Zang M, Grogg K, Winkler T, Vidal Melo M. Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury. Critical Care 2023, 27: 307. PMID: 37537654, PMCID: PMC10401825, DOI: 10.1186/s13054-023-04591-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeFour-dimensional computed tomographyPEEP strategyLung aerationEnd-inspirationLung injuryTidal recruitmentComputed tomographyRegistration-based techniqueEnd-expirationCyclic recruitmentMechanisms of ventilator-induced lung injuryVentilator-induced lung injuryPotential outcome benefitsBackgroundPositive end-expiratory pressureRespiratory distress syndromeHigh-resolution CTRespiratory system complianceEnd-expiratory pressureSaline lung lavageLung massDistress syndromeInspiratory increaseRecruitable lungSurfactant depletion model