Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury
Zeng C, Zhu M, Motta-Ribeiro G, Lagier D, Hinoshita T, Zang M, Grogg K, Winkler T, Vidal Melo M. Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury. Critical Care 2023, 27: 307. PMID: 37537654, PMCID: PMC10401825, DOI: 10.1186/s13054-023-04591-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeFour-dimensional computed tomographyPEEP strategyLung aerationEnd-inspirationLung injuryTidal recruitmentComputed tomographyRegistration-based techniqueEnd-expirationCyclic recruitmentMechanisms of ventilator-induced lung injuryVentilator-induced lung injuryPotential outcome benefitsBackgroundPositive end-expiratory pressureRespiratory distress syndromeHigh-resolution CTRespiratory system complianceEnd-expiratory pressureSaline lung lavageLung massDistress syndromeInspiratory increaseRecruitable lungSurfactant depletion model