2024
Stepwise pathways from the olfactory cortex to central hub regions in the human brain
Menelaou G, Diez I, Zelano C, Zhou G, Persson J, Sepulcre J, Olofsson J. Stepwise pathways from the olfactory cortex to central hub regions in the human brain. Human Brain Mapping 2024, 45: e26760. PMID: 39688149, PMCID: PMC11651219, DOI: 10.1002/hbm.26760.Peer-Reviewed Original ResearchConceptsDefault-mode networkCortical hubsHuman brainDefault-mode network regionsAnterior olfactory nucleusFunctional connectivity researchProcessing rewardOrbitofrontal cortexAnterior insulaOlfactory tubercleFrontal sulcusPiriform cortexOlfactory cortexCortical subregionsOlfactory nucleusAssociation cortexLanguage acquisitionParietal operculumNeural activityTemporal regionsCortical networksSynchronous neural activityOlfactory pathwaySensory cortexOlfactory systemReorganization of integration and segregation networks in brain-based visual impairment
Diez I, Troyas C, Bauer C, Sepulcre J, Merabet L. Reorganization of integration and segregation networks in brain-based visual impairment. NeuroImage Clinical 2024, 44: 103688. PMID: 39432973, PMCID: PMC11535411, DOI: 10.1016/j.nicl.2024.103688.Peer-Reviewed Original ResearchIntraparietal sulcusReduced gray matter volumeResting state functional connectivityCerebral visual impairmentGray matter volumeFunctional network architectureMultimodal integration areasMode networkMatter volumeNeurotypical developmentFunctional connectivityVisual processingEnvironmental experiencesCerebral connectivityPrimary visual cortexHuman brainConnectome analysisBrain injuryNetwork organizationVisual cortexImpairmentInvestigate differencesCompared to controlsFunctional changesParticipantsMultimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption
d’Oleire Uquillas F, Sefik E, Li B, Trotter M, Steele K, Seidlitz J, Gesue R, Latif M, Fasulo T, Zhang V, Kislin M, Verpeut J, Cohen J, Sepulcre J, Wang S, Gomez J. Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption. Molecular Psychiatry 2024, 1-15. PMID: 39390225, DOI: 10.1038/s41380-024-02769-1.Peer-Reviewed Original ResearchAutism spectrum disorderNeurotypical childrenFunctional connectivityMultimodal evidenceFunctional connectivity analysisModel of autismCerebro-cerebellar pathwayAtypical connectivitySpectrum disorderConnectivity analysisEarly adolescenceASD childrenCerebellar influenceBehavioral developmentNeurodevelopmental disordersFunctional-structural relationshipsCerebellar structuresAutismYoung childhoodLiving brainCerebellumFunctional synchronizationThalamusSignificant lateralizationCerebral cortexCortical hubs of highly superior autobiographical memory
Orwig W, Diez I, Bueichekú E, Pedale T, Parente F, Campolongo P, Schacter D, Sepulcre J, Santangelo V. Cortical hubs of highly superior autobiographical memory. Cortex 2024, 179: 14-24. PMID: 39094240, DOI: 10.1016/j.cortex.2024.06.018.Peer-Reviewed Original ResearchConceptsSuperior autobiographical memoryAutobiographical memoryCortical hubsWhole-brain connectivity analysisPattern of increased connectivityResting-state fMRI dataWhole-brain analysisAutobiographical memory networkPosterior cingulate cortexMidline areaSeed-based analysisFunctional brain connectivityGraph theory analysisCingulate cortexNeural underpinningsNeuroimaging studiesEnhance memoryRemembering eventsBrain regionsControl participantsConnectivity analysisFMRI dataBrain connectivityCortical regionsWhole-brainTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive power432. Success and Failure of Connectome-Based Prediction of Cognitive Functioning in Early Psychosis
O'Neill A, Pax M, Sepulcre J, Camprodon J, Holt D, Noble S, Roffman J, Eryilmaz H. 432. Success and Failure of Connectome-Based Prediction of Cognitive Functioning in Early Psychosis. Biological Psychiatry 2024, 95: s276-s277. DOI: 10.1016/j.biopsych.2024.02.931.Peer-Reviewed Original ResearchSpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patternsMulti-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Communications Medicine 2024, 4: 65. PMID: 38580832, PMCID: PMC10997795, DOI: 10.1038/s43856-024-00497-9.Peer-Reviewed Original ResearchMemory declineMedial anterior prefrontal cortexAging brainWhole-brain voxel-wiseAnterior prefrontal cortexRegion-of-interest analysisResting-state functional MRIObjective memory declineOccipito-parietal regionsMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksPrefrontal cortexMnemonic anosognosiaTau burdenBiomarkers of AD pathologyMode networkParieto-occipital areasFunctional network connectivity disruptionFunctional MRIBrain phenotypesVoxel-wiseBehavioral conditionsBehavioral biomarkersA late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study
Beucke J, Diez I, Sepulcre J, Mundorf A, Kaufmann C, Orr S, Pitman R, Shin L. A late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study. Journal Of Psychiatric Research 2024, 171: 230-237. PMID: 38316103, PMCID: PMC11113072, DOI: 10.1016/j.jpsychires.2024.01.032.Peer-Reviewed Original ResearchConceptsAmygdalar responsesCombat exposureCombat stressSymptoms of post-traumatic stress disorderPost-traumatic stress disorderTermination of stress exposureCombat-exposed veteransDiscordant twin studiesImpact brain functionAmygdalar functionStress disorderStress exposureAcute stressTwin studiesTwin pairsCombat experienceNeurogenetic mechanismsBrain functionEarly adulthoodEffects of ageConfounding effects of ageTwin siblingsVeteransPsychosocial evidenceGene expression
2023
Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080294.Peer-Reviewed Original ResearchMnemonic anosognosiaOccipito-parietal regionsMemory declineBrain phenotypesSelf-referential brain networkObjective memory testsObjective memory declineResting-state fMRIPosterior cerebral cortexMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksGraph theory metricsTau burdenNeurocognitive profileBiomarkers of AD pathologyMemory testMemory impairmentBetween-group comparisonsFunctional network connectivity disruptionBrain networksAging brainAnosognosiaBehavioral conditionsSpatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition
Bueichekú E, Diez I, Kim C, Becker A, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079747.Peer-Reviewed Original ResearchLC integrityLocus coeruleusLower cognitive performanceLongitudinal tau accumulationCognitive performanceEmergence of cognitive declineAssociated with lower cognitive performanceTemporal cortex areasIn vivo neuroimaging dataTau accumulationTau progressionCortical tau depositionAlzheimer's diseaseNeuroimaging studiesMTL structuresNeuroimaging dataAD-related pathologyCognitive declineCortex areaPartial correlationMisfolded tau proteinContext of ADGLM analysisSites of tauLipid biosynthetic processRelationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity
Cacciamani F, Gagliardi G, Mimmack K, Qiao K, Bueichekú E, Marshall G, Sepulcre J, Diez I, Vannini P. Relationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079806.Peer-Reviewed Original ResearchAwareness of cognitive declineResting-state functional connectivityLinear regression modelsSelf-referential networkHigher tau burdenFunctional connectivityCognitive declineRegression modelsTau accumulationAlzheimer's diseaseImpaired resting-state functional connectivityAlzheimer's disease spectrumResting-state fMRI dataAssociated with tau accumulationDorsal attention networkReduced awarenessWithin-network connectivityModulatory roleLow awarenessTau burdenEffects of tauCognitive function indicesTau interactionsSalience networkTau pathologyCerebral systems underlying anosognosia for memory loss in aging and Alzheimer’s disease
Mimmack K, Qiao K, Gagliardi G, Bueichekú E, Cacciamani F, Wang S, Udeogu O, Marshall G, Sepulcre J, Vannini P. Cerebral systems underlying anosognosia for memory loss in aging and Alzheimer’s disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080305.Peer-Reviewed Original ResearchBetween-network connectivityFrontoparietal networkSensory-motor networkMemory awarenessFunctional connectivityDecreased connectivityAssociated with increased connectivitySensory-motorWithin-network connectivitySelf-referential networkCognitive Function InstrumentAwareness of cognitive declineResting-state fMRISensory-motor relationshipsWhole-brain connectivityAlzheimer's diseaseSymptoms of Alzheimer's diseaseMultiple comparison correctionSalience networkDefault modeDorsal attentionBrain regionsFC patternsPartners' scoresMedial visualSpatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Journal Of Neuroscience 2023, 44: e0488232023. PMID: 38123362, PMCID: PMC10869152, DOI: 10.1523/jneurosci.0488-23.2023.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyCognitive changesCognitive declineAssociated with cognitive changesAssociated with early cognitive declineAging Brain StudyEarly cognitive declineTau depositionCognitive scoresBrain studiesHuman brainTau pathologyOlder adultsTau accumulationTau associationImpaired associationAD symptomsClinical trajectoryCortical patternsTauBraak stageSpatiotemporal levelsTemporal accumulationBraakFuture increasesAssociation of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognitionMagnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor
Lin J, Kang X, Lu H, Zhang D, Bian X, Zhou J, Hu J, Zhang D, Sepulcre J, Pan L, Lou X. Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor. Neurotherapeutics 2023, 20: 1755-1766. PMID: 37843768, PMCID: PMC10684443, DOI: 10.1007/s13311-023-01442-9.Peer-Reviewed Original ResearchConceptsMRgFUS thalamotomyET patientsEssential tremorMagnetic resonance-guided focused ultrasoundMatched health controlsPostoperative 6 monthsTremor symptomsHealth controlsFunctional MR imagingMRgFUSPatientsFeatures of Parkinson's diseaseThalamotomyRobust alterationsMR imagingPosterior cingulate cortexFocused ultrasoundCingulate cortexSymptomsNeurological diseasesAlterationsParkinson's diseaseSymptom predictionDiseaseTremorCreativity at rest: Exploring functional network connectivity of creative experts
Orwig W, Setton R, Diez I, Bueichekú E, Meyer M, Tamir D, Sepulcre J, Schacter D. Creativity at rest: Exploring functional network connectivity of creative experts. Network Neuroscience 2023, 7: 1022-1033. PMID: 37781148, PMCID: PMC10473280, DOI: 10.1162/netn_a_00317.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFunctional connectivityReduced connectivityAssociated with creative abilityReplicate prior findingsVisual cortexBrain network organizationStudies of functional connectivityFunctional brain connectivityLateral visual cortexFunctional network connectivityNeuroscience of creativityComplex brain processesNeuroimaging studiesGeneration of novel ideasBrain processesBrain connectivityConnectivity profilesCreative performanceCreative behaviorCortexPrimary visual cortexMagnetic resonance imagingNetwork organizationNegative associationCortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
Gagliardi G, Rodriguez-Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz A, Properzi M, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid. Communications Medicine 2023, 3: 106. PMID: 37528163, PMCID: PMC10394044, DOI: 10.1038/s43856-023-00324-7.Peer-Reviewed Original ResearchLogical Memory delayed recallEpisodic memory declineMemory declineCortical mean diffusivityAmyloid-positive participantsEntorhinal cortexAmyloid statusCognitively normal older adultsHarvard Aging Brain StudyInferior temporal lobeNormal older adultsOlder adultsAging Brain StudyCognitively normal participantsTau accumulationCognitively normal individualsBrain microstructural changesInteraction effectsTau PET imagingDelayed recallBaseline amyloid statusTemporal lobeEntorhinal tauNormal participantsBrain studiesAssociation of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive compositeCorrelations between APOE4 status and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 status and regional amyloid and tau burdens in cognitively normal older individuals. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.065023.Peer-Reviewed Original ResearchApolipoprotein epsilon 4Standardized uptake value ratioCarrier statusCortical thicknessPositron emission tomographyApolipoprotein epsilon 4 statusTau burdenCognitively normal older individualsAPOE4 carriersRegional amyloidNon-carriersCross-sectional studyNormal older individualsCognitively normal participantsFlorbetapir positron emission tomographyNormal cognitive functionAPOE4 non-carriersAssociated with amyloid depositionRegional tau burdenCognitive functionAD-related biomarkersAge differencesPhosphorylated tauNormal participantsClinical characteristics