2018
Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders
Williams B, Jalilianhasanpour R, Matin N, Fricchione G, Sepulcre J, Keshavan M, LaFrance W, Dickerson B, Perez D. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. Journal Of Psychiatric Research 2018, 102: 230-237. PMID: 29702433, PMCID: PMC6005758, DOI: 10.1016/j.jpsychires.2018.04.006.Peer-Reviewed Original ResearchConceptsInsecure attachmentCoping stylesCortical thicknessMaladaptive copingFunctional neurological disorder (FND)/conversion disorderMotor functional neurological disorderSelf-reported attachmentStructural neuroimaging studiesConnor-Davidson Resilience Scale scoresRelationship Scales QuestionnaireRight hippocampal volumeFreeSurfer cortical thicknessCoping Scale-RevisedSubcortical volumetric analysesMagnetic resonance imaging studiesCortical thickness analysisFunctional neurological disorderResilience Scale scoresWithin-group analysisDismissing attachmentGender-specific effectsParahippocampal thicknessMotor FNDPredisposing vulnerabilitiesSubcortical analyses
2017
Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder
Perez D, Williams B, Matin N, LaFrance W, Costumero-Ramos V, Fricchione G, Sepulcre J, Keshavan M, Dickerson B. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2017, 88: 1052. PMID: 28844071, DOI: 10.1136/jnnp-2017-316359.Peer-Reviewed Original ResearchConceptsPathophysiology of functional neurological disorderFunctional neurological disorderInsular volumeTrait anxietyWithin-group analysisSalience networkAmygdalar volumeMental healthVolumetric differencesFunctional neurological disorder cohortsEmotional problemsSevere physical health impairmentMotor FND subtypesSecondary within-group analysisRight amygdalar volumeElevated trait anxietySalience network regionsPhysical health impairmentAssociated with mental healthNeurological symptom severityHealth statusAssociated with role limitationsImpaired mental healthAffective symptomsWell-being deficitsCingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders
Perez D, Matin N, Barsky A, Costumero-Ramos V, Makaretz S, Young S, Sepulcre J, LaFrance W, Keshavan M, Dickerson B. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. Journal Of Neurology Neurosurgery & Psychiatry 2017, 88: 491. PMID: 28416565, PMCID: PMC5497745, DOI: 10.1136/jnnp-2016-314998.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexChildChild AbuseConversion DisorderDominance, CerebralFemaleGray MatterGyrus CinguliHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalLife Change EventsMagnetic Resonance ImagingMaleMiddle AgedNervous System DiseasesOrgan SizePsychophysiologic DisordersStatistics as TopicStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional neurological symptomsFunctional neurological disorderAnterior cingulate cortexSelf-report measuresInsular volumeChildhood abuseVolumetric associationsSymptom severityPost-traumatic stress disorder symptom severityAssociated with left hippocampal volumeAdverse early-life eventsFunctional neurological disorder patientsLeft hippocampal volumeAdverse life eventsPatient Health Questionnaire-15Neurological symptom severityEarly-life eventsACC volumeDisorder subscaleGender-specific effectsCingulate cortexStress disorderHippocampal volume