2017
Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level.
Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple G. Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level. Revista De Neurologia 2017, 64: 97-104. PMID: 28128426, DOI: 10.33588/rn.6403.2016211.Peer-Reviewed Original ResearchConceptsNeuropsychological batteryTasks measuring working memoryNormative dataOriginal normative sampleInformation processing speedIdentified cognitive impairmentWorking memoryVerbal memoryNeuropsychological assessmentNormative sampleCognitive testsProcessing speedHealthy control groupStandard scoresCognitive impairmentMultiple sclerosisEducation levelHealthy controlsSex variableMemoryTaskHealthy volunteersRegression analysisBatteryControl group
2015
The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity
Abad E, Sepulcre J, Martinez-Lapiscina E, Zubizarreta I, Garcia-Ojalvo J, Villoslada P. The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity. Multiple Sclerosis And Related Disorders 2015, 4: 387-394. PMID: 26346784, DOI: 10.1016/j.msard.2015.07.002.Peer-Reviewed Original Research
2011
Computational classifiers for predicting the short-term course of Multiple sclerosis
Bejarano B, Bianco M, Gonzalez-Moron D, Sepulcre J, Goñi J, Arcocha J, Soto O, Carro U, Comi G, Leocani L, Villoslada P. Computational classifiers for predicting the short-term course of Multiple sclerosis. BMC Neurology 2011, 11: 67. PMID: 21649880, PMCID: PMC3118106, DOI: 10.1186/1471-2377-11-67.Peer-Reviewed Original ResearchConceptsClinical end pointsCentral motor conduction timeMotor evoked potentialsMultiple sclerosisDiagnostic accuracyEnd pointsMRI lesion loadCourse of multiple sclerosisShort-term prognosisCourse of MSPrognosis of multiple sclerosisMotor conduction timeEDSS changeDisability progressionShort-term disabilityProspective cohortDisease courseClinical dataBaseline disabilityShort-term courseClinical variablesIndependent cohortMS patientsGray matter volumeBackgroundThe aim
2010
Lexical access changes in patients with multiple sclerosis: A two-year follow-up study
Sepulcre J, Peraita H, Goñi J, Arrondo G, Martincorena I, Duque B, de Mendizábal N, Masdeu J, Villoslada P. Lexical access changes in patients with multiple sclerosis: A two-year follow-up study. Journal Of Clinical And Experimental Neuropsychology 2010, 33: 169-175. PMID: 20835944, DOI: 10.1080/13803395.2010.499354.Peer-Reviewed Original ResearchConceptsConfrontation namingRetrieval of lexical informationSemantic verbal fluency taskPhonemic verbal fluency testVerbal fluency taskVerbal fluency testFluency taskTwo-year follow-up studyFluency testSwitching scoresLexical informationMultiple sclerosisMS patientsCommunication abilityHealthy controlsFollow-up studyNamesImpairmentYear follow-upConfrontationTaskScoresRetrievalSclerosisAbility
2009
Brain pathways of verbal working memory A lesion–function correlation study
Sepulcre J, Masdeu J, Pastor M, Goñi J, Barbosa C, Bejarano B, Villoslada P. Brain pathways of verbal working memory A lesion–function correlation study. NeuroImage 2009, 47: 773-778. PMID: 19393745, DOI: 10.1016/j.neuroimage.2009.04.054.Peer-Reviewed Original ResearchConceptsVerbal working memoryWorking memoryWhite matter pathwaysWhite matter regionsMatter regionsVerbal working memory taskDisrupted white matter pathwaysRight cerebellar white matterWorking memory taskWhite matter connectivityMemory taskGray matter regionsCognitive processesCognitive functionThalamo-cortical projectionsInformation processingHuman brainMagnetic resonance imagingMemoryCerebellar white matterWhite matterWhite matter lesionsLeft-sided predominanceBrainMultiple sclerosis patientsContribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway
Sepulcre J, Goñi J, Masdeu J, Bejarano B, de Mendizábal N, Toledo J, Villoslada P. Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway. JAMA Neurology 2009, 66: 173-179. PMID: 19204153, DOI: 10.1001/archneurol.2008.562.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleus atrophyGM atrophyMultiple sclerosisOptic pathway lesionsOptical radiationWhite matterOptic radiation lesionsGray matterWM regionsRegional GM atrophyWhite matter lesionsLesion probability mapsVoxel-based analysisT1 lesionsPathway lesionsLateral geniculate nucleusRadiation lesionsPresence of lesionsMultiple Sclerosis CenterGray matter atrophyOptic pathwayMultiple sclerosis plaquesAtrophyLesionsAxonal injuryFractal dimension analysis of grey matter in multiple sclerosis
Esteban F, Sepulcre J, de Miras J, Navas J, de Mendizábal N, Goñi J, Quesada J, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. Journal Of The Neurological Sciences 2009, 282: 67-71. PMID: 19167728, DOI: 10.1016/j.jns.2008.12.023.Peer-Reviewed Original ResearchConceptsGray matterMagnetic resonance imagingMultiple sclerosisVoxel-based morphometry approachExtensive grey matterAttack of MST1 MRI sequencesT2 lesion loadShorter disease durationWhite matter abnormalitiesGM abnormalitiesMorphometry approachGM morphologyGM atrophyMeasures of GMLong-term disabilityDisease durationHealthy controlsHuman brainMS patientsLesion loadPatientsAbnormalitiesResonance imagingMRI sequences
2008
RETINAL NERVE FIBER LAYER IS ASSOCIATED WITH BRAIN ATROPHY IN MULTIPLE SCLEROSIS
Villoslada P, Sepulcre J, Toledo J, Bejarano B. RETINAL NERVE FIBER LAYER IS ASSOCIATED WITH BRAIN ATROPHY IN MULTIPLE SCLEROSIS. Neurology 2008, 71: 1747-1748. PMID: 19015496, DOI: 10.1212/01.wnl.0000339375.92578.7e.Peer-Reviewed Original ResearchMapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain
Sepulcre J, Masdeu J, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor M, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. NeuroImage 2008, 42: 1237-1243. PMID: 18585467, DOI: 10.1016/j.neuroimage.2008.05.038.Peer-Reviewed Original ResearchConceptsAnterior temporal stemDeclarative verbal memoryLiving human brainVerbal memoryTemporal stemDisrupted white matter pathwaysVerbal memory processesHuman brainFronto-occipital fasciculusWhite matter pathwaysMemory processesLeft hemisphereBrain pathwaysWhite matter regionsWhite matter lesionsAnterior limbThalamic regionsMemory storageMatter regionsMagnetic resonance imagingBrainInternal capsuleWhite matterMemoryMultiple sclerosis patientsRetinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Multiple Sclerosis Journal 2008, 14: 906-912. PMID: 18573835, DOI: 10.1177/1352458508090221.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerHeidelberg retinal tomographyOptical coherence tomographyMultiple sclerosisRetinal nerve fiber layer thickness measurementsRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessCompare optical coherence tomographyNerve fiber layer atrophyNerve fiber layerAssociated with physical disabilityRetinal tomographyFiber layerCoherence tomographyAxonal lossNeurological examinationMatched controlsSymbol Digit Modalities TestTissue changesPatientsCognitive disabilitiesAtrophyMS evolutionDetect thinningTomographyMemory decline evolves independently of disease activity in MS
Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Multiple Sclerosis Journal 2008, 14: 947-953. PMID: 18573817, DOI: 10.1177/1352458508089686.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestSymbol Digit Modalities Test performanceCognitive impairmentBrief Repeatable Battery-NeuropsychologyVerbal memory performanceNatural history of cognitive impairmentExecutive functionVerbal memoryMemory performanceMemory declineHistory of cognitive impairmentCognitive evaluationMultiple sclerosisModal testingDisease activityDisability progressionDisabilityImpairmentMemoryEDSS changeStudy entryParameters of disease activityMS patientsProspective cohortRelapseA computational analysis of protein-protein interaction networks in neurodegenerative diseases
Goñi J, Esteban F, de Mendizábal N, Sepulcre J, Ardanza-Trevijano S, Agirrezabal I, Villoslada P. A computational analysis of protein-protein interaction networks in neurodegenerative diseases. BMC Systems Biology 2008, 2: 52. PMID: 18570646, PMCID: PMC2443111, DOI: 10.1186/1752-0509-2-52.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBrainComputational BiologyComputer SimulationGene Expression RegulationModels, BiologicalMultiple SclerosisProtein BindingConceptsProtein-protein interactionsAnalysis of protein-protein interaction networksProtein-protein interaction informationProtein-protein interaction networkAlzheimer's diseaseNeurodegenerative diseasesProtein-protein interaction analysisSeed proteinStudy of biological networksGene expression studiesDNA array experimentsProperties of proteinsMultifactorial neurodegenerative diseaseAD brainInteraction networkExpression studiesBiological networksGene expressionBackgroundRecent developmentsMolecular pathwaysGenesArray experimentsComputational analysisParameters of degreePathwayHLA‐DR2 and White Matter Lesion Distribution in MS
Sepulcre J, Masdeu J, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA‐DR2 and White Matter Lesion Distribution in MS. Journal Of Neuroimaging 2008, 18: 328-331. PMID: 18482373, DOI: 10.1111/j.1552-6569.2008.00259.x.Peer-Reviewed Original ResearchConceptsHLA-DR2Magnetic resonance imagingMultiple sclerosisLesion distributionHuman leukocyte antigen DR2White matterAntigen DR2Regional distribution of white matterGenetic risk factorsMRI patternRisk factorsResonance imagingDistribution of white matterDisease phenotypePatientsLesionsLesion phenotypeDiseasePhenotypeLesion mapsRegional distributionIL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis
Martinez‐Forero I, Garcia‐Munoz R, Martinez‐Pasamar S, Inoges S, de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez‐Diez B, Melero I, Bendandi M, Villoslada P. IL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. European Journal Of Immunology 2008, 38: 576-586. PMID: 18200504, DOI: 10.1002/eji.200737271.Peer-Reviewed Original ResearchConceptsTr1 cellsCD4(+) cellsIL-10R signalingIL-10MS patientsIL-10 stimulationIL-10RMultiple sclerosisIL-10R signaling pathwayIL-10RA geneCell type 1Anti-CD46 antibodiesExpression of cytokinesSTAT-3 phosphorylationInduced in vitroReal-time PCRCell therapyIL-10RASuppression assaysPatientsSuppressor activityType 1Baseline levelsCell functionSTAT-3
2007
A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases. PLOS ONE 2007, 2: e1222. PMID: 18030350, PMCID: PMC2077806, DOI: 10.1371/journal.pone.0001222.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBayes TheoremCalcium-Binding ProteinsCase-Control StudiesEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansImmunotherapyIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLymphocyte ActivationMaleMembrane ProteinsMiceMice, Inbred C57BLMultiple SclerosisReverse Transcriptase Polymerase Chain ReactionSerrate-Jagged ProteinsT-LymphocytesConceptsAutoimmune diseasesMultiple sclerosisTherapeutic targetDevelopment of autoimmune diseasesControlling T cell activationExperimental autoimmune encephalomyelitisT cell proliferationTreatment of miceT cell activationTherapy induced changesLevels similar to controlsIn vitro treatmentGene networksGene interactionsTh1 functionTh2 functionTreg functionImmunomodulatory therapyAutoimmune encephalomyelitisSimilar to controlsIngenuity databaseImmune interventionT cellsDisease courseAgonist peptideAntibodies against Epstein–Barr virus and herpesvirus type 6 are associated with the early phases of Multiple Sclerosis
Riverol M, Sepulcre J, Fernandez-Alonso M, Uccelli A, Brieva L, Rubio M, Rodriguez A, Fernandez-Diez B, Villoslada P. Antibodies against Epstein–Barr virus and herpesvirus type 6 are associated with the early phases of Multiple Sclerosis. Journal Of Neuroimmunology 2007, 192: 184-185. PMID: 17869349, DOI: 10.1016/j.jneuroim.2007.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, ViralFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHumansMaleMiddle AgedMultiple SclerosisDiagnostic accuracy of retinal abnormalities in predicting disease activity in MS
Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology 2007, 68: 1488-1494. PMID: 17470751, DOI: 10.1212/01.wnl.0000260612.51849.ed.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyCohort StudiesDisease ProgressionEarly DiagnosisFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOptic NerveOptic NeuritisPhlebitisPredictive Value of TestsProspective StudiesRetinaRetinal DiseasesRetinal Ganglion CellsRetinal VeinTomography, Optical CoherenceConceptsRetinal nerve fiber layerRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessRetinal periphlebitisOptical coherence tomographyOptic neuritisDisease activityMultiple sclerosisGadolinium-enhancing lesion volumeNerve fiber layer atrophyAssociated with disease activityNerve fiber layerPredicting disease activityExpanded Disability Status ScaleLonger disease durationMatter volumeBaseline MRI studyDisability Status ScaleRetinal evaluationOphthalmologic evaluationWhite matter volumeTemporal quadrantMultiple sclerosis activityRetinal abnormalitiesOCT scansFractal dimension and white matter changes in multiple sclerosis
Esteban F, Sepulcre J, de Mendizábal N, Goñi J, Navas J, de Miras J, Bejarano B, Masdeu J, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. NeuroImage 2007, 36: 543-549. PMID: 17499522, DOI: 10.1016/j.neuroimage.2007.03.057.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleFractalsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMultiple SclerosisConceptsMultiple sclerosisHealthy controlsCentrum semiovale levelWhite matterConventional MR imagingGray-white matter interfaceMR imaging sectionsVoxel-based morphometry approachCentral nervous systemConventional magnetic resonanceWhite matter changesWM abnormalitiesPatientsMR imagingMS lesionsNervous systemBrain white matterMatter changesMagnetic resonanceNAWMBrain WMBrains of patientsLesionsBrainEarly phase
2006
Methylthioadenosine reverses brain autoimmune disease
Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García‐Trevijano E, Berasain C, Corrales F, Avila M, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Annals Of Neurology 2006, 60: 323-334. PMID: 16786535, DOI: 10.1002/ana.20895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAmyloid beta-Protein PrecursorAnimalsCytokinesDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunologic FactorsLymphocytesMacrophagesMaleMiddle AgedMultiple SclerosisNitric Oxide Synthase Type IIPhytohemagglutininsRatsRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricThionucleosidesConceptsExperimental autoimmune encephalomyelitisAutoimmune diseasesChronic relapsing EAET cell activation in vivoAcute experimental autoimmune encephalomyelitisExperimental autoimmune encephalomyelitis animalsPeripheral blood mononuclear cellsMultiple sclerosisChronic EAE modelHealthy control subjectsInhibiting brain inflammationBlood mononuclear cellsProduction of antiinflammatory cytokinesRodent experimental autoimmune encephalomyelitisImmunomodulatory activityPrevention of inhibitorsTranscription factor nuclear factor-kappaB.Cytokine gene expressionNuclear factor-kappaB.Real-time polymerase chain reactionReduced brain damageT cell signalingMultiple sclerosis patientsAutoimmune encephalomyelitisEAE modelCognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test
Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Multiple Sclerosis Journal 2006, 12: 187-195. PMID: 16629422, DOI: 10.1191/1352458506ms1258oa.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestBRB-N testsCognitive impairmentBRB-NHealthy controlsCognitive measuresPhysical disabilityMS patientsMultiple sclerosisModal testingImpairmentBriefIndividual testsCut-off valueDisabilityEducation levelRelapsing MSZ-scoreProgressive MSPatientsMonitoring patientsIllnessLevel of controlSclerosisStandard deviation