2019
Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults
Uquillas F, Jacobs H, Schultz A, Hanseeuw B, Buckley R, Sepulcre J, Pascual-Leone A, Donovan N, Johnson K, Sperling R, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cerebral Cortex 2019, 30: 1974-1983. PMID: 31696223, PMCID: PMC7132950, DOI: 10.1093/cercor/bhz217.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCognitively unimpaired older adultsMetamemory processesMemory performanceOlder adultsMidline regionVentromedial prefrontal cortexFunctional magnetic resonance imaging signalsHarvard Aging Brain StudyJudgments of learningAging Brain StudyAlzheimer's diseaseMemory successPrefrontal cortexAssociated with overestimationNeural substratesTau pathologyBilateral hippocampiBrain studiesJOLsCohort of older adultsMagnetic resonance imagingCognitionAD dementiaTau deposition
2018
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs H, Hedden T, Schultz A, Sepulcre J, Perea R, Amariglio R, Papp K, Rentz D, Sperling R, Johnson K. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience 2018, 21: 424-431. PMID: 29403032, PMCID: PMC5857215, DOI: 10.1038/s41593-018-0070-z.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory declineCingulate cortexHippocampal volumeTau accumulationAssociated with increased mean diffusivityCognitively healthy older individualsBaseline hippocampal volumeAmyloid-positive individualsWhite matter connectivityAmyloid-negative individualsPreclinical Alzheimer's diseaseAmyloid pathologyAnimal models of Alzheimer's diseaseHealthy older individualsTau pathology propagationModel of Alzheimer's diseaseAlzheimer's diseaseTau positron emission tomographyMemory performanceNeural vulnerabilityCingulum bundleOlder individualsPositron emission tomographyMean diffusivity
2010
The semantic organization of the animal category: evidence from semantic verbal fluency and network theory
Goñi J, Arrondo G, Sepulcre J, Martincorena I, Vélez de Mendizábal N, Corominas-Murtra B, Bejarano B, Ardanza-Trevijano S, Peraita H, Wall D, Villoslada P. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory. Cognitive Processing 2010, 12: 183-196. PMID: 20938799, DOI: 10.1007/s10339-010-0372-x.Peer-Reviewed Original ResearchConceptsSemantic verbal fluencyVerbal fluency testSemantic memoryVerbal fluencyFluency testFluency experienceSemantic organizationHuman memoryNatural categoriesAnimal categoriesStored knowledgeRetrieval mechanismRecovery criteriaCo-occurrence approachKnowledge of conceptsConceptual structureMemorySemantic informationNetwork modelCo-occurring conceptsNetwork outcomesHuman ratersFluencyExpert human ratersHuman evaluationFunctional-Anatomic Fractionation of the Brain's Default Network
Andrews-Hanna J, Reidler J, Sepulcre J, Poulin R, Buckner R. Functional-Anatomic Fractionation of the Brain's Default Network. Neuron 2010, 65: 550-562. PMID: 20188659, PMCID: PMC2848443, DOI: 10.1016/j.neuron.2010.02.005.Peer-Reviewed Original ResearchConceptsMedial temporal lobe subsystemNetwork of brain regionsBrain's default networkHuman functional imagingPersonally significant eventsDefault networkMidline coreSelf-relevanceMental sceneSpontaneous cognitionBrain regionsFunctional imagingSpontaneous actsSignificant eventsCognitionIntrinsic activityMemoryDecision makingBrainHypothesis
2009
Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis
Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 509-516. PMID: 19282416, DOI: 10.1177/1352458508101321.Peer-Reviewed Original ResearchConceptsCognitive impairmentBrain synchronyBRB-NCognitive functionBRB-N scoresEffect of MS lesionsEfficient cognitive processingBrain oscillatory activityHealthy controlsCentral nervous systemWhite matter tractsLong white matter tractsAuditory amplitude modulationExecutive functionVerbal memoryCognitive performanceDistant cortical areasBrain networksCognitive processesMultiple sclerosisBrain synchronizationYears of disease evolutionAuditory stimuliCortical areasBrain damage
2008
Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain
Sepulcre J, Masdeu J, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor M, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. NeuroImage 2008, 42: 1237-1243. PMID: 18585467, DOI: 10.1016/j.neuroimage.2008.05.038.Peer-Reviewed Original ResearchConceptsAnterior temporal stemDeclarative verbal memoryLiving human brainVerbal memoryTemporal stemDisrupted white matter pathwaysVerbal memory processesHuman brainFronto-occipital fasciculusWhite matter pathwaysMemory processesLeft hemisphereBrain pathwaysWhite matter regionsWhite matter lesionsAnterior limbThalamic regionsMemory storageMatter regionsMagnetic resonance imagingBrainInternal capsuleWhite matterMemoryMultiple sclerosis patientsRetinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Multiple Sclerosis Journal 2008, 14: 906-912. PMID: 18573835, DOI: 10.1177/1352458508090221.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerHeidelberg retinal tomographyOptical coherence tomographyMultiple sclerosisRetinal nerve fiber layer thickness measurementsRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessCompare optical coherence tomographyNerve fiber layer atrophyNerve fiber layerAssociated with physical disabilityRetinal tomographyFiber layerCoherence tomographyAxonal lossNeurological examinationMatched controlsSymbol Digit Modalities TestTissue changesPatientsCognitive disabilitiesAtrophyMS evolutionDetect thinningTomography