2023
Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive composite
2021
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities
Leaston J, Ferris C, Kulkarni P, Chandramohan D, van de Ven A, Qiao J, Timms L, Sepulcre J, Fakhri G, Ma C, Normandin M, Gharagouzloo C. Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PLOS ONE 2021, 16: e0256749. PMID: 34449808, PMCID: PMC8396782, DOI: 10.1371/journal.pone.0256749.Peer-Reviewed Original ResearchConceptsVascular abnormalitiesAPOE-e4Contrast-enhanced magnetic resonance imagingBlood-brain-barrier leakageNeurovascular dysfunctionSmall vessel abnormalitiesMagnetic resonance imagingTri-synaptic circuitBlood-brain-barrierCross-sectional studyFemale ratsSignificant signal increaseHyper-vascularizationCerebrovascular abnormalitiesVessel abnormalitiesNeurovascular imagingQUTE-CEBrain volumeAnimal modelsPathological causesAbnormalitiesHistological validationImaging modalitiesResonance imaging
2016
Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease
Sepulcre J, Masdeu J. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods In Molecular Biology 2016, 1303: 509-519. PMID: 26235088, DOI: 10.1007/978-1-4939-2627-5_31.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional magnetic resonance imagingAlzheimer's diseaseEarly stages of Alzheimer's diseaseOxygen level-dependentMagnetic resonance imagingStages of Alzheimer's diseaseNeurobiological changesStructural neuroimagingBrain networksBrain regionsBrains of patientsPostmortem studiesLevel-dependentNeurobiology of ADFunctional networksPostmortem dataBrainQuiet wakefulnessTau depositionResonance imagingTherapeutic interventionsNetwork propertiesNeurobiologyNeuroimaging
2013
Individual Variability in Functional Connectivity Architecture of the Human Brain
Mueller S, Wang D, Fox M, Yeo B, Sepulcre J, Sabuncu M, Shafee R, Lu J, Liu H. Individual Variability in Functional Connectivity Architecture of the Human Brain. Neuron 2013, 77: 586-595. PMID: 23395382, PMCID: PMC3746075, DOI: 10.1016/j.neuron.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnimalsBrain MappingCerebral CortexFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedIndividualityMacaca mulattaMagnetic Resonance ImagingMaleMeta-Analysis as TopicMiddle AgedNeural PathwaysOxygenPhotic StimulationPredictive Value of TestsRegression AnalysisTime FactorsConceptsResting-state functional MRIHeteromodal association cortexFunctional connectivity architectureCognitive domainsUnimodal cortexIndividual differencesFunctional MRIFunctional connectivityAssociation cortexConnection variablesLong-range connectivityBrain anatomyCortical thicknessBrain evolutionHuman brainCortexSulcal depthIntersubject variabilityStatistical mapsIndividual variabilityConnectivity architectureBrainFunctional variablesLocal connectivityCortical expansion
2012
Network assemblies in the functional brain
Sepulcre J, Sabuncu M, Johnson K. Network assemblies in the functional brain. Current Opinion In Neurology 2012, 25: 384-391. PMID: 22766721, PMCID: PMC3471530, DOI: 10.1097/wco.0b013e328355a8e8.Peer-Reviewed Original Research
2007
A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases. PLOS ONE 2007, 2: e1222. PMID: 18030350, PMCID: PMC2077806, DOI: 10.1371/journal.pone.0001222.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBayes TheoremCalcium-Binding ProteinsCase-Control StudiesEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansImmunotherapyIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLymphocyte ActivationMaleMembrane ProteinsMiceMice, Inbred C57BLMultiple SclerosisReverse Transcriptase Polymerase Chain ReactionSerrate-Jagged ProteinsT-LymphocytesConceptsAutoimmune diseasesMultiple sclerosisTherapeutic targetDevelopment of autoimmune diseasesControlling T cell activationExperimental autoimmune encephalomyelitisT cell proliferationTreatment of miceT cell activationTherapy induced changesLevels similar to controlsIn vitro treatmentGene networksGene interactionsTh1 functionTh2 functionTreg functionImmunomodulatory therapyAutoimmune encephalomyelitisSimilar to controlsIngenuity databaseImmune interventionT cellsDisease courseAgonist peptide
2006
Methylthioadenosine reverses brain autoimmune disease
Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García‐Trevijano E, Berasain C, Corrales F, Avila M, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Annals Of Neurology 2006, 60: 323-334. PMID: 16786535, DOI: 10.1002/ana.20895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAmyloid beta-Protein PrecursorAnimalsCytokinesDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunologic FactorsLymphocytesMacrophagesMaleMiddle AgedMultiple SclerosisNitric Oxide Synthase Type IIPhytohemagglutininsRatsRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricThionucleosidesConceptsExperimental autoimmune encephalomyelitisAutoimmune diseasesChronic relapsing EAET cell activation in vivoAcute experimental autoimmune encephalomyelitisExperimental autoimmune encephalomyelitis animalsPeripheral blood mononuclear cellsMultiple sclerosisChronic EAE modelHealthy control subjectsInhibiting brain inflammationBlood mononuclear cellsProduction of antiinflammatory cytokinesRodent experimental autoimmune encephalomyelitisImmunomodulatory activityPrevention of inhibitorsTranscription factor nuclear factor-kappaB.Cytokine gene expressionNuclear factor-kappaB.Real-time polymerase chain reactionReduced brain damageT cell signalingMultiple sclerosis patientsAutoimmune encephalomyelitisEAE model