2021
Divergent connectomic organization delineates genetic evolutionary traits in the human brain
Bueichekú E, Gonzalez-de-Echavarri J, Ortiz-Teran L, Montal V, d’Oleire Uquillas F, De Marcos L, Orwig W, Kim C, Ortiz-Teran E, Basaia S, Diez I, Sepulcre J. Divergent connectomic organization delineates genetic evolutionary traits in the human brain. Scientific Reports 2021, 11: 19692. PMID: 34608211, PMCID: PMC8490416, DOI: 10.1038/s41598-021-99082-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiological EvolutionBrainBrain MappingConnectomeData AnalysisEvolution, MolecularFemaleHumansImage Processing, Computer-AssistedMaleQuantitative Trait, HeritableYoung AdultConceptsEvolutionary traitsHomo sapiens lineageDN/dS ratiosPositive selectionCellular functionsEvolutionary pathwaysGene expressionGenetic expressionSapiens lineageBiological dataCo-localizationDivergent pathwaysFunctional specializationTraitsBiological qualityResting-state dataPathwayHuman brain functionSimian ancestorsExpressionConnectome organizationCognitive trajectoriesAncestorLineagesBrain functionDistance disintegration characterizes node‐level topological dysfunctions in cocaine addiction
Costumero V, Negre P, Bustamante J, Fuentes‐Claramonte P, Adrián‐Ventura J, Palomar‐García M, Miró‐Padilla A, Llopis J, Sepulcre J, Barrós‐Loscertales A. Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction. Addiction Biology 2021, 26: e13072. PMID: 34137121, DOI: 10.1111/adb.13072.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCocaine-Related DisordersHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPatient AcuityConceptsCocaine use disorderFunctional magnetic resonance imagingLateral orbitofrontal cortexGraph theory measuresOrbitofrontal cortexCocaine use disorder individualsRight lateral orbitofrontal cortexResting state functional magnetic resonance imagingMiddle frontal cortexRight temporal poleLength of abstinenceSeverity of dependenceRight rolandic operculumHealthy controlsYears of educationVentral striatumIntellectual functioningLeft insulaLeft hippocampusFrontal cortexRolandic operculumTemporal poleTemporal cortexUse disorderNodal efficiencyConnectivity adaptations in dopaminergic systems define the brain maturity of investors
Ortiz-Teran E, Diez I, Sepulcre J, Lopez-Pascual J, Ortiz T. Connectivity adaptations in dopaminergic systems define the brain maturity of investors. Scientific Reports 2021, 11: 11671. PMID: 34083626, PMCID: PMC8175592, DOI: 10.1038/s41598-021-91227-x.Peer-Reviewed Original ResearchConceptsSenior investorsGray matter volumeDopamine-related pathwaysInvestment decisionsStructural brain connectivityBodily stress responsesFinancial tradingReward processingDopaminergic systemInvestorsMatter volumeBrain connectivityBrain maturationAssociated with adrenalineBodily awarenessBrain anatomyWork experienceHuman brainInvestmentBrainNoradrenaline biosynthesisStress responseConnectivity adaptation
2019
Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder
Pretus C, Marcos‐Vidal L, Martínez‐García M, Picado M, Ramos‐Quiroga J, Richarte V, Castellanos F, Sepulcre J, Desco M, Vilarroya Ó, Carmona S. Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder. Human Brain Mapping 2019, 40: 4645-4656. PMID: 31322305, PMCID: PMC6865796, DOI: 10.1002/hbm.24727.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional connectivitySensory regionsNeural hubCognitive functionResting-state functional magnetic resonance imagingAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSeed regionPatterns of functional connectivityDefault-mode networkDeficit hyperactivity disorderFunctional networksPrimary sensory regionsFunctional overconnectivityAttention-deficit/hyperactivityNeuroimaging studiesMode networkHyperactivity disorderLow connectivity degreeRs-fMRIPattern of alterationsSeverity ScaleSensory inputMagnetic resonance imaging
2018
Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders
Williams B, Jalilianhasanpour R, Matin N, Fricchione G, Sepulcre J, Keshavan M, LaFrance W, Dickerson B, Perez D. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. Journal Of Psychiatric Research 2018, 102: 230-237. PMID: 29702433, PMCID: PMC6005758, DOI: 10.1016/j.jpsychires.2018.04.006.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultBrainDissociative DisordersFemaleHumansImage Processing, Computer-AssistedIndividualityMagnetic Resonance ImagingMaleMiddle AgedMovement DisordersNervous System DiseasesPsychometricsConceptsInsecure attachmentCoping stylesCortical thicknessMaladaptive copingFunctional neurological disorder (FND)/conversion disorderMotor functional neurological disorderSelf-reported attachmentStructural neuroimaging studiesConnor-Davidson Resilience Scale scoresRelationship Scales QuestionnaireRight hippocampal volumeFreeSurfer cortical thicknessCoping Scale-RevisedSubcortical volumetric analysesMagnetic resonance imaging studiesCortical thickness analysisFunctional neurological disorderResilience Scale scoresWithin-group analysisDismissing attachmentGender-specific effectsParahippocampal thicknessMotor FNDPredisposing vulnerabilitiesSubcortical analysesLocal functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder
Marcos‐Vidal L, Martínez‐García M, Pretus C, Garcia‐Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos F, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder. Human Brain Mapping 2018, 39: 2442-2454. PMID: 29473262, PMCID: PMC6866394, DOI: 10.1002/hbm.24013.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderND childrenFunctional connectivityAttention-deficit/hyperactivityFronto-parietalGroup differencesSomatomotor areasAttention-deficit/hyperactivity disorder symptomsSeverity of ADHD symptomsAttention-deficit/hyperactivity disorder diagnosisAtypical functional connectivityMaturational lag hypothesisVentral attention networkAtypical developmental patternPotential group differencesIncreased local connectivityFunctional networksHuman brain changesMultiple brain regionsLocal functional connectivityImmature functional stateBrain functional networksSeverity of clinical symptomsADHD symptomsSomatomotor regions
2017
Partial volume correction for PET quantification and its impact on brain network in Alzheimer’s disease
Yang J, Hu C, Guo N, Dutta J, Vaina L, Johnson K, Sepulcre J, Fakhri G, Li Q. Partial volume correction for PET quantification and its impact on brain network in Alzheimer’s disease. Scientific Reports 2017, 7: 13035. PMID: 29026139, PMCID: PMC5638902, DOI: 10.1038/s41598-017-13339-7.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBrainCohort StudiesFemaleHumansImage Processing, Computer-AssistedMaleNerve NetPositron-Emission TomographyConceptsQuantitative accuracy of PET imagesSpatial resolution of PET scannersAccuracy of PET imagesPET scannerBrain networksPET imagingQuantitative accuracyPartial volume effectsClassification performanceImage registrationPositron emission tomography quantificationPartial volume correctionSpatial resolutionJoint entropyVolume correctionNetwork structure analysisCorrected imagesVolume effectClinical datasetsParameter settingsPositron emission tomographyClassification testsCompare network propertiesNoise sensitivityComplexity analysis of cortical surface detects changes in future Alzheimer's disease converters
de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters. Human Brain Mapping 2017, 38: 5905-5918. PMID: 28856799, PMCID: PMC5745046, DOI: 10.1002/hbm.23773.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseCerebral CortexCognitive DysfunctionCohort StudiesDisease ProgressionFemaleFractalsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleOrgan SizePrognosisWhite MatterAssociation of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease
Xia C, Makaretz S, Caso C, McGinnis S, Gomperts S, Sepulcre J, Gomez-Isla T, Hyman B, Schultz A, Vasdev N, Johnson K, Dickerson B. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology 2017, 74: 427-436. PMID: 28241163, PMCID: PMC5470368, DOI: 10.1001/jamaneurol.2016.5755.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAtrophyCarbolinesCerebral CortexFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsRetrospective StudiesTau ProteinsConceptsStructural magnetic resonance imagingAlzheimer's diseaseCortical atrophyHyperphosphorylated tau proteinClinical phenotypeTau in vivoAssociation in vivoAtypical Alzheimer's diseaseMagnetic resonance imagingTau proteinMeasure amyloid burdenPositron emission tomographicNeurofibrillary tanglesMeasure cortical thicknessOutpatient referral centerDisease-modifying therapeuticsTau PET imagingCarbon 11-labeled Pittsburgh Compound BCognitive functionIn vivo evidenceCortical regionsResonance imagingPostmortem studiesCortical thicknessNeurodegenerative diseasesTau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAniline CompoundsBrainBrain MappingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysOxygenPositron-Emission TomographyTau ProteinsThiazolesConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association
2016
Epicenters of dynamic connectivity in the adaptation of the ventral visual system
Prčkovska V, Huijbers W, Schultz A, Ortiz‐Teran L, Peña‐Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Human Brain Mapping 2016, 38: 1965-1976. PMID: 28029725, PMCID: PMC5342908, DOI: 10.1002/hbm.23497.Peer-Reviewed Original ResearchConceptsFunctional connectivityReorganization of functional connectivityVentral visual systemDynamic functional connectivityCognitive processing areasRepetition paradigmBrain systemsRepetition-suppressionAssociation cortexSynchrony changesConnectivity changesGraph theory methodsPrimary visual areaSensory stimuliConnectivity reorganizationVisual areasNeuronal responsesProcessing areasCortexDistant connectionsEnhanced synchronyBrainDegree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms
Beucke J, Sepulcre J, Buhlmann U, Kathmann N, Moody T, Feusner J. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. European Neuropsychopharmacology 2016, 26: 1657-1666. PMID: 27514293, PMCID: PMC5316290, DOI: 10.1016/j.euroneuro.2016.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaBasal GangliaBody Dysmorphic DisordersFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysObsessive-Compulsive DisorderPrefrontal CortexPsychiatric Status Rating ScalesYoung AdultConceptsObsessive-compulsive disorderBody dysmorphic disorderFunctional magnetic resonance imagingOrbitofrontal cortexDysmorphic disorderSymptom severityFunctional connectivityYale-Brown Obsessive-Compulsive ScaleResting-state functional connectivityDegree connectivityFace processing taskObsessive-Compulsive ScaleBrain-behavior associationsDegree of functional connectivityCompulsive symptomsObsessive-compulsiveAmygdalar connectivityCompulsive behaviorsObsessive thoughtsBrain hyperactivitySymptom provocationDistant connectionsBrain areasDiagnostic groupsBasal gangliaMeasuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications
Teipel S, Grothe M, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications. Journal Of The International Neuropsychological Society 2016, 22: 138-163. PMID: 26888613, DOI: 10.1017/s1355617715000995.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBrain MappingCerebral CortexHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve NetOxygenConceptsCortical connectivityMild cognitive impairmentClinical applicationFunctional cortical connectivityMagnetic resonance imagingWhite matter bundlesResting-state functional magnetic resonance imagingDiffusion tensor imagingBlood oxygen level-dependent activityPre-clinicalEEG rhythmsCerebral reserve capacityResonance imagingNetwork pathologyAttention-related networksIn vivoMild AD dementia patientsTensor imagingBrain circuitsCognitively intact elderly individualsConnectivity measuresElderly individualsPatientsAlzheimer's diseaseFunctional coupling
2014
Default mode network subsystem alterations in obsessive–compulsive disorder
Beucke J, Sepulcre J, Eldaief M, Sebold M, Kathmann N, Kaufmann C. Default mode network subsystem alterations in obsessive–compulsive disorder. The British Journal Of Psychiatry 2014, 205: 376-382. PMID: 25257066, DOI: 10.1192/bjp.bp.113.137380.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve NetObsessive-Compulsive DisorderSeverity of Illness IndexYoung AdultConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderAssociated with self-referential processingModels of obsessive-compulsive disorderSeed-based resting-state functional connectivityObsessive-compulsive disorder groupHistory of affective disorderResting-state functional connectivityFunctional magnetic resonance imagingSelf-referential processingCorticostriatal brain regionsLife-time historyMode network componentsNeurobiological modelsAffective disordersBrain regionsFunctional connectivityReduced connectivityNeural systemsMedical statusAttention networkDisordered backgroundMagnetic resonance imagingDisordersNetwork integration
2013
In vivo characterization of the early states of the amyloid-beta network
Sepulcre J, Sabuncu M, Becker A, Sperling R, Johnson K. In vivo characterization of the early states of the amyloid-beta network. Brain 2013, 136: 2239-2252. PMID: 23801740, PMCID: PMC3692037, DOI: 10.1093/brain/awt146.Peer-Reviewed Original ResearchConceptsAmyloid-bAlzheimer's diseasePittsburgh compound B positron emission tomography imagingPrecuneus/posterior cingulate cortexMedial temporal lobeRegional brain atrophyAlzheimer's disease pathologyAmyloid-betaOrbitofrontal cortexCingulate cortexAmygdala nucleiTemporal lobeCortical regionsAssociated with accumulationHub propertiesEmission tomography imagingNeurodegenerative diseasesBrain atrophyDisease pathologyAlzheimerHippocampusAbnormal accumulationCortexIn vivo characterizationElderly subjectsIndividual Variability in Functional Connectivity Architecture of the Human Brain
Mueller S, Wang D, Fox M, Yeo B, Sepulcre J, Sabuncu M, Shafee R, Lu J, Liu H. Individual Variability in Functional Connectivity Architecture of the Human Brain. Neuron 2013, 77: 586-595. PMID: 23395382, PMCID: PMC3746075, DOI: 10.1016/j.neuron.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnimalsBrain MappingCerebral CortexFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedIndividualityMacaca mulattaMagnetic Resonance ImagingMaleMeta-Analysis as TopicMiddle AgedNeural PathwaysOxygenPhotic StimulationPredictive Value of TestsRegression AnalysisTime FactorsConceptsResting-state functional MRIHeteromodal association cortexFunctional connectivity architectureCognitive domainsUnimodal cortexIndividual differencesFunctional MRIFunctional connectivityAssociation cortexConnection variablesLong-range connectivityBrain anatomyCortical thicknessBrain evolutionHuman brainCortexSulcal depthIntersubject variabilityStatistical mapsIndividual variabilityConnectivity architectureBrainFunctional variablesLocal connectivityCortical expansion
2012
Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain
Sepulcre J, Sabuncu M, Yeo T, Liu H, Johnson K. Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain. Journal Of Neuroscience 2012, 32: 10649-10661. PMID: 22855814, PMCID: PMC3483645, DOI: 10.1523/jneurosci.0759-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsBrain MappingCerebral CortexFemaleFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleMental ProcessesModels, NeurologicalNeural PathwaysOxygenSensationYoung AdultConceptsHigher-order brain systemsMultimodal integration networkOrganization of brain regionsHuman brainCognitive processing systemsPosterior parietal cortexBrain systemsNeuroimaging researchParietal cortexBrain regionsInternal cognitionPerceptual integrationFunctional connectomeModality-relatedMultimodal organizationPerceptual convergenceMultimodal integrationCortexBrainMultimode processesCognitionCoherence experimentsConnectomeConnective axisProcessing systemNetwork assemblies in the functional brain
Sepulcre J, Sabuncu M, Johnson K. Network assemblies in the functional brain. Current Opinion In Neurology 2012, 25: 384-391. PMID: 22766721, PMCID: PMC3471530, DOI: 10.1097/wco.0b013e328355a8e8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainHumansImage Processing, Computer-AssistedModels, NeurologicalNerve NetNeural PathwaysNeuroimaging
2011
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
Drzezga A, Becker J, Van Dijk K, Sreenivasan A, Talukdar T, Sullivan C, Schultz A, Sepulcre J, Putcha D, Greve D, Johnson K, Sperling R. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011, 134: 1635-1646. PMID: 21490054, PMCID: PMC3102239, DOI: 10.1093/brain/awr066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloidAniline CompoundsBenzothiazolesBrain MappingCerebral CortexCognition DisordersFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenPositron-Emission TomographyStatistics as TopicThiazolesConceptsWhole-brain connectivityDisruption of functional connectivityCortical hubsEarly functional consequencesMild cognitive impairmentFunctional connectivityAmyloid burdenCognitive impairmentNon-demented older individualsVoxel-based morphometry measuresAmyloid-positive patientsStructural magnetic resonanceDisruption of connectivityEmission tomographyCerebral glucose metabolismAlzheimer-type neurodegenerationAssociated with neuronal dysfunctionClinical Alzheimer's diseaseNon-demented subjectsCognitive symptomsIncreased amyloid burdenBrain regionsFunctional disconnectionNeuronal dysfunctionWhole-brainLocalization of focal epileptic discharges using functional connectivity magnetic resonance imaging.
Stufflebeam S, Liu H, Sepulcre J, Tanaka N, Buckner R, Madsen J. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. Journal Of Neurosurgery 2011, 114: 1693-7. PMID: 21351832, PMCID: PMC3248962, DOI: 10.3171/2011.1.jns10482.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingEpilepsies, PartialFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetoencephalographyMaleYoung AdultConceptsEpileptic dischargesRefractory epilepsyMedically refractory epilepsyFocal epileptic dischargesLocalized epileptic dischargesSeizure onset zoneMagnetic resonance imagingFunctional connectivity magnetic resonance imagingStatistically significant increaseSurgical treatmentEpileptogenic areaSpontaneous brain activityInvasive electroencephalographyOnset zonePatientsResonance imagingMR imagingHigh-spatial resolutionNoninvasive methodSignificant increasePresurgical mappingFocal regionFCMREpilepsy