HLA‐DR2 and White Matter Lesion Distribution in MS
Sepulcre J, Masdeu J, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA‐DR2 and White Matter Lesion Distribution in MS. Journal Of Neuroimaging 2008, 18: 328-331. PMID: 18482373, DOI: 10.1111/j.1552-6569.2008.00259.x.Peer-Reviewed Original ResearchConceptsHLA-DR2Magnetic resonance imagingMultiple sclerosisLesion distributionHuman leukocyte antigen DR2White matterAntigen DR2Regional distribution of white matterGenetic risk factorsMRI patternRisk factorsResonance imagingDistribution of white matterDisease phenotypePatientsLesionsLesion phenotypeDiseasePhenotypeLesion mapsRegional distributionAssociation of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
Pampliega O, Domercq M, Villoslada P, Sepulcre J, Rodríguez-Antigüedad A, Matute C. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. Journal Of Neuroimmunology 2008, 195: 194-198. PMID: 18378006, DOI: 10.1016/j.jneuroim.2008.01.011.Peer-Reviewed Original ResearchConceptsMultiple sclerosisGlutamate homeostasisMS patientsPlasma glutamate levelsRelapsing multiple sclerosisGlutamate transporter EAAT2Glutamate plasma levelsGlutamate levelsRelapsing MSPlasma levelsControl subjectsTransporter expressionTransporter EAAT2Glutamate excitotoxicityGlutamate concentrationTissue damageMutant genotypesGlutamateEAAT2PatientsSclerosisPolymorphismHomeostasis