2020
Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade
Labayru G, Jimenez‐Marin A, Fernández E, Villanua J, Zulaica M, Cortes J, Díez I, Sepulcre J, de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade. Annals Of Clinical And Translational Neurology 2020, 7: 1802-1815. PMID: 32881379, PMCID: PMC7545612, DOI: 10.1002/acn3.51163.Peer-Reviewed Original ResearchConceptsVoxel Based MorphometryHealthy controlsFronto-subcortical networksPatterns of brain atrophyMultimodal integration networkExecutive function testsBrain structural abnormalitiesRegional brain volumesGM damageDM1 patientsNeuropsychological testsNeurodevelopmental originBrain changesPediatric onset patientsGM lossFrontal regionsVBM analysisWM volumeBrain abnormalitiesBrain volumeCognitive outcomesFollow-up MRI studiesHC groupYoung adulthoodImpairment assessment
2018
PET staging of amyloidosis using striatum
Hanseeuw B, Betensky R, Mormino E, Schultz A, Sepulcre J, Becker J, Jacobs H, Buckley R, LaPoint M, Vannini P, Donovan N, Chhatwal J, Marshall G, Papp K, Amariglio R, Rentz D, Sperling R, Johnson K, Initiative F, Study A. PET staging of amyloidosis using striatum. Alzheimer's & Dementia 2018, 14: 1281-1292. PMID: 29792874, PMCID: PMC6219621, DOI: 10.1016/j.jalz.2018.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesAmyloidosisApolipoprotein E4Brain ConcussionCognitive DysfunctionCorpus StriatumDisease ProgressionFemaleFollow-Up StudiesHumansImage Interpretation, Computer-AssistedLongitudinal StudiesMalePositron-Emission TomographyProspective StudiesSeverity of Illness IndexConceptsPositron emission tomographyHippocampal volumeCortical amyloidInvolvement of cortexPositron emission tomography dataStriatal signalingPositron emission tomography classificationAmyloid positron emission tomographyStriatumCognitive declineCortical measuresCortexPostmortem dataCognitionCortical depositsEmission tomographyIncreased predictive powerDementia progressionAdvanced amyloidosisDementia researchAlzheimerPET dataStriatalFollow-up dataPredictive power
2017
Functional network integrity presages cognitive decline in preclinical Alzheimer disease
Buckley R, Schultz A, Hedden T, Papp K, Hanseeuw B, Marshall G, Sepulcre J, Smith E, Rentz D, Johnson K, Sperling R, Chhatwal J. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology 2017, 89: 29-37. PMID: 28592457, PMCID: PMC5496516, DOI: 10.1212/wnl.0000000000004059.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer Cognitive CompositePreclinical Alzheimer Cognitive Composite scoreClinically normal older adultsNormal older adultsPreclinical Alzheimer's diseaseRs-fcMRICognitive declineBaseline connectivityResting-state functional connectivity MRIControl networkAD-related cognitive declineMeasures of network integrationFunctional connectivity MRIAlzheimer's diseaseNeuropsychological follow-upControl network connectivityOlder adultsFunctional network integrationCompound B PETPittsburgh compound B PETPredictor of ratingsNetwork integrationDorsal attentionCognitive compositeYears of follow-upThe association between tau PET and retrospective cortical thinning in clinically normal elderly
LaPoint M, Chhatwal J, Sepulcre J, Johnson K, Sperling R, Schultz A. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage 2017, 157: 612-622. PMID: 28545932, PMCID: PMC5772972, DOI: 10.1016/j.neuroimage.2017.05.049.Peer-Reviewed Original ResearchConceptsTemporal regionsCortical thinningCortical ROIsCortical thicknessRetrospective longitudinal analysisRight temporal regionAssociated with neuronal lossBaseline ageNormal cohortNeuronal lossRate of cortical thinningLeft cuneusPathologyMedial temporal regionsVolumetric ROIsReference regionAtrophyThick cross-sectionsCortical regionsBilateral parahippocampal cortexLongitudinal atrophyLongitudinal analysisLeft superior temporal sulcusCortexBrain studies
2013
Individual Variability in Functional Connectivity Architecture of the Human Brain
Mueller S, Wang D, Fox M, Yeo B, Sepulcre J, Sabuncu M, Shafee R, Lu J, Liu H. Individual Variability in Functional Connectivity Architecture of the Human Brain. Neuron 2013, 77: 586-595. PMID: 23395382, PMCID: PMC3746075, DOI: 10.1016/j.neuron.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnimalsBrain MappingCerebral CortexFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedIndividualityMacaca mulattaMagnetic Resonance ImagingMaleMeta-Analysis as TopicMiddle AgedNeural PathwaysOxygenPhotic StimulationPredictive Value of TestsRegression AnalysisTime FactorsConceptsResting-state functional MRIHeteromodal association cortexFunctional connectivity architectureCognitive domainsUnimodal cortexIndividual differencesFunctional MRIFunctional connectivityAssociation cortexConnection variablesLong-range connectivityBrain anatomyCortical thicknessBrain evolutionHuman brainCortexSulcal depthIntersubject variabilityStatistical mapsIndividual variabilityConnectivity architectureBrainFunctional variablesLocal connectivityCortical expansion
2010
Lexical access changes in patients with multiple sclerosis: A two-year follow-up study
Sepulcre J, Peraita H, Goñi J, Arrondo G, Martincorena I, Duque B, de Mendizábal N, Masdeu J, Villoslada P. Lexical access changes in patients with multiple sclerosis: A two-year follow-up study. Journal Of Clinical And Experimental Neuropsychology 2010, 33: 169-175. PMID: 20835944, DOI: 10.1080/13803395.2010.499354.Peer-Reviewed Original ResearchConceptsConfrontation namingRetrieval of lexical informationSemantic verbal fluency taskPhonemic verbal fluency testVerbal fluency taskVerbal fluency testFluency taskTwo-year follow-up studyFluency testSwitching scoresLexical informationMultiple sclerosisMS patientsCommunication abilityHealthy controlsFollow-up studyNamesImpairmentYear follow-upConfrontationTaskScoresRetrievalSclerosisAbility
2008
Memory decline evolves independently of disease activity in MS
Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Multiple Sclerosis Journal 2008, 14: 947-953. PMID: 18573817, DOI: 10.1177/1352458508089686.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestSymbol Digit Modalities Test performanceCognitive impairmentBrief Repeatable Battery-NeuropsychologyVerbal memory performanceNatural history of cognitive impairmentExecutive functionVerbal memoryMemory performanceMemory declineHistory of cognitive impairmentCognitive evaluationMultiple sclerosisModal testingDisease activityDisability progressionDisabilityImpairmentMemoryEDSS changeStudy entryParameters of disease activityMS patientsProspective cohortRelapse
2006
Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study
Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle G, Miller D, Thompson A. Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study. JAMA Neurology 2006, 63: 1175-1180. PMID: 16908748, DOI: 10.1001/archneur.63.8.1175.Peer-Reviewed Original ResearchConceptsPrimary progressive MSMultiple sclerosisBilateral thalamic atrophyYears of follow-upPrimary progressive multiple sclerosisYears of symptom onsetHealthy control subjectsGray matterProgressive multiple sclerosisDecreased GM volumeGradient-recalled echo sequenceMagnetic resonance imagingInfratentorial atrophyCross-sectional studyVoxel-based morphometric analysisInfratentorial areaDeep GMThalamic atrophyComparing patientsControl subjectsFollow-upProgressive MSSymptom onsetGray matter atrophyLesion load