2017
Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level.
Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple G. Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level. Revista De Neurologia 2017, 64: 97-104. PMID: 28128426, DOI: 10.33588/rn.6403.2016211.Peer-Reviewed Original ResearchConceptsNeuropsychological batteryTasks measuring working memoryNormative dataOriginal normative sampleInformation processing speedIdentified cognitive impairmentWorking memoryVerbal memoryNeuropsychological assessmentNormative sampleCognitive testsProcessing speedHealthy control groupStandard scoresCognitive impairmentMultiple sclerosisEducation levelHealthy controlsSex variableMemoryTaskHealthy volunteersRegression analysisBatteryControl group
2011
Computational classifiers for predicting the short-term course of Multiple sclerosis
Bejarano B, Bianco M, Gonzalez-Moron D, Sepulcre J, Goñi J, Arcocha J, Soto O, Carro U, Comi G, Leocani L, Villoslada P. Computational classifiers for predicting the short-term course of Multiple sclerosis. BMC Neurology 2011, 11: 67. PMID: 21649880, PMCID: PMC3118106, DOI: 10.1186/1471-2377-11-67.Peer-Reviewed Original ResearchConceptsClinical end pointsCentral motor conduction timeMotor evoked potentialsMultiple sclerosisDiagnostic accuracyEnd pointsMRI lesion loadCourse of multiple sclerosisShort-term prognosisCourse of MSPrognosis of multiple sclerosisMotor conduction timeEDSS changeDisability progressionShort-term disabilityProspective cohortDisease courseClinical dataBaseline disabilityShort-term courseClinical variablesIndependent cohortMS patientsGray matter volumeBackgroundThe aim
2010
Lexical access changes in patients with multiple sclerosis: A two-year follow-up study
Sepulcre J, Peraita H, Goñi J, Arrondo G, Martincorena I, Duque B, de Mendizábal N, Masdeu J, Villoslada P. Lexical access changes in patients with multiple sclerosis: A two-year follow-up study. Journal Of Clinical And Experimental Neuropsychology 2010, 33: 169-175. PMID: 20835944, DOI: 10.1080/13803395.2010.499354.Peer-Reviewed Original ResearchConceptsConfrontation namingRetrieval of lexical informationSemantic verbal fluency taskPhonemic verbal fluency testVerbal fluency taskVerbal fluency testFluency taskTwo-year follow-up studyFluency testSwitching scoresLexical informationMultiple sclerosisMS patientsCommunication abilityHealthy controlsFollow-up studyNamesImpairmentYear follow-upConfrontationTaskScoresRetrievalSclerosisAbility
2009
Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis
Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 509-516. PMID: 19282416, DOI: 10.1177/1352458508101321.Peer-Reviewed Original ResearchConceptsCognitive impairmentBrain synchronyBRB-NCognitive functionBRB-N scoresEffect of MS lesionsEfficient cognitive processingBrain oscillatory activityHealthy controlsCentral nervous systemWhite matter tractsLong white matter tractsAuditory amplitude modulationExecutive functionVerbal memoryCognitive performanceDistant cortical areasBrain networksCognitive processesMultiple sclerosisBrain synchronizationYears of disease evolutionAuditory stimuliCortical areasBrain damage
2008
Memantine induces reversible neurologic impairment in patients with MSSYMBOLSYMBOL
Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MSSYMBOLSYMBOL. Neurology 2008, 72: 1630-1633. PMID: 19092106, DOI: 10.1212/01.wnl.0000342388.73185.80.Peer-Reviewed Original ResearchMeSH KeywordsBrainCognition DisordersCross-Over StudiesDisability EvaluationDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleExcitatory Amino Acid AntagonistsHumansIatrogenic DiseaseMemantineMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsPlacebosQuality of LifeSecondary PreventionSeverity of Illness IndexTreatment FailureConceptsQuality of lifeCognitive impairmentCognitive domainsBrief Repeatable Battery-NeuropsychologyIncreased muscle weaknessImprove cognitive performanceMultiple sclerosisNeurological symptomsBaseline disabilityWalking difficultiesUnstable gaitVerbal memoryCognitive performanceCognitive dysfunctionStopping medicationPilot trialNormative dataWorsening of neurological symptomsImpair patients' qualityReverse neurologic impairmentPatients' qualityMuscle weaknessMemantineMemantine armDouble-blind
2005
Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis
Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine 2005, 32: 111-116. PMID: 16246570, DOI: 10.1016/j.cyto.2005.08.005.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisability EvaluationHumansInterferon-gammaMultiple Sclerosis, Relapsing-RemittingConceptsCD8+ T cellsRelapsing-remitting MST-cell phenotypeCD8+ lymphocytesDisability scoresIFN-gammaT cellsMultiple sclerosisPeripheral blood T-cell phenotypesPatients treated with interferon-betaHealthy controlsAssociated with disability scoresBlood T-cell phenotypesPeripheral T-cell phenotypePercentage of IFN-gammaEffects of immunomodulatory treatmentsIL-4 producing CD4Decrease of IFN-gammaRelapsing-remitting MS patientsRelapsing-remitting multiple sclerosisPathogenesis of multiple sclerosisCD4+ lymphocytesT cell populationsPresence of IFN-gammaPro-inflammatory profile