2024
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive powerSpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patterns
2023
Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Journal Of Neuroscience 2023, 44: e0488232023. PMID: 38123362, PMCID: PMC10869152, DOI: 10.1523/jneurosci.0488-23.2023.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyCognitive changesCognitive declineAssociated with cognitive changesAssociated with early cognitive declineAging Brain StudyEarly cognitive declineTau depositionCognitive scoresBrain studiesHuman brainTau pathologyOlder adultsTau accumulationTau associationImpaired associationAD symptomsClinical trajectoryCortical patternsTauBraak stageSpatiotemporal levelsTemporal accumulationBraakFuture increasesAssociation of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognitionAssociation of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive composite
2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAlleles
2021
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Molecular Psychiatry 2021, 26: 7813-7822. PMID: 34588623, PMCID: PMC8873001, DOI: 10.1038/s41380-021-01290-z.Peer-Reviewed Original ResearchConceptsCortical mean diffusivityCognitive declineOlder adultsCognitively normal older adultsHarvard Aging Brain StudyCortical microstructureInferior temporal tauProgression to mild cognitive impairmentNormal older adultsBrain structural changesAmyloid-bAging Brain StudyCompound B PETLongitudinal cognitive declineAD-vulnerable regionsHippocampal atrophy ratesCognitively normal individualsAlzheimer's diseaseMild cognitive impairmentCognitive slopesStructural MRIEntorhinal tauCognitive AssessmentCognitive impairmentLongitudinal cognitionNetwork interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
Kim C, Montal V, Diez I, Orwig W, Initiative A, Sepulcre J. Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging. Human Brain Mapping 2021, 42: 2990-3004. PMID: 33955621, PMCID: PMC8193537, DOI: 10.1002/hbm.25350.Peer-Reviewed Original ResearchConceptsCognitively normal older adultsAmyloid-betaPathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseTau depositionPositron emission tomographyGeneral cognitive impairmentTau neurofibrillary tanglesAlzheimer's diseaseNormal older adultsOlder adultsAmyloid-beta depositionCognitive test scoresTau pathogenesisAD vulnerable areasNeurofibrillary tanglesHeteromodal areasTau accumulationCognitive changesCognitive deteriorationCognitive impairmentCognitive declinePathological hallmarkPreclinical ADCognitive levelLongitudinal predictive modeling of tau progression along the structural connectome
Yang F, Chowdhury S, Jacobs H, Sepulcre J, Wedeen V, Johnson K, Dutta J. Longitudinal predictive modeling of tau progression along the structural connectome. NeuroImage 2021, 237: 118126. PMID: 33957234, PMCID: PMC8260445, DOI: 10.1016/j.neuroimage.2021.118126.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyTau progressionDiffusion tensor imagingLongitudinal predictive modelsAlzheimer's Disease Neuroimaging InitiativeAlzheimer's diseaseTau PET scansPositron emission tomographyLongitudinal positron emission tomographyTau neurofibrillary tanglesAging Brain StudyTau measuresNeurofibrillary tanglesTau transmissionStructural connectivity mapsPET scansCognitive declineBrain studiesPhysiological processesTensor imagingTauStructural connectomeGoodness of model fitClosed-form solutionPrediction framework
2020
Central neurogenetic signatures of the visuomotor integration system
Bueichekú E, Aznárez-Sanado M, Diez I, Uquillas F, Ortiz-Terán L, Qureshi A, Suñol M, Basaia S, Ortiz-Terán E, Pastor M, Sepulcre J. Central neurogenetic signatures of the visuomotor integration system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 6836-6843. PMID: 32144139, PMCID: PMC7104395, DOI: 10.1073/pnas.1912429117.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAutism Spectrum DisorderBrain MappingCalcium ChannelsCohort StudiesEpilepsies, MyoclonicFemaleHumansMaleMiddle AgedMotor CortexNAV1.1 Voltage-Gated Sodium ChannelNeurodevelopmental DisordersPrader-Willi SyndromeProteinsPsychomotor PerformanceT-Box Domain ProteinsVisual CortexVisual PerceptionConceptsAutism spectrum disorderVisuomotor integrationNeurogenetic syndromesAllen Human Brain AtlasHuman cortexHuman Brain AtlasWilliams syndromeSpectrum disorderConnectome approachVisuomotor impairmentFragile XSystems neuroscienceVisuomotorHuman brainCortexFunctional impairmentBiological basisPrader-WilliBrain atlasesExpression traitsNeuronal organizationGene expression traitsDisordersImpairmentNeural development
2019
Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiology Of Aging 2019, 88: 51-60. PMID: 31941578, PMCID: PMC7085436, DOI: 10.1016/j.neurobiolaging.2019.12.005.Peer-Reviewed Original ResearchConceptsAssociated with lower global cognitionCognitive impairmentAlzheimer's diseaseBrain network dysfunctionAD-related changesMild cognitive impairmentFrontoparietal networkSalience networkMode networkStrength of connectionsNetwork-based investigationsGlobal cognitionNetwork dysfunctionAD-related conditionsBrain connectivityConnectivity changesCortical regionsConnection distanceInvestigation of brain connectivityAD spectrumVoxel levelHealthy controlsDistance of connectionBrainPathways of connectivityDecreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults
Vannini P, Uquillas F, Jacobs H, Sepulcre J, Gatchel J, Amariglio R, Hanseeuw B, Papp K, Hedden T, Rentz D, Pascual-Leone A, Johnson K, Sperling R. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. NeuroImage Clinical 2019, 24: 102097. PMID: 31795044, PMCID: PMC6879982, DOI: 10.1016/j.nicl.2019.102097.Peer-Reviewed Original ResearchConceptsFeeling-of-knowingEpisodic feeling-of-knowingCognitively unimpaired older adultsMeta-memoryMedial temporal lobe regionsOlder adultsFace-name pairsRegion-of-interest analysisTemporal lobe regionsAlzheimer's diseaseVoxel-wise correlationSemantic knowledge networkTemporal poleLobe regionsEntorhinal cortexNon-famousSensitive clinical indicatorMulti-tracer PETMemory efficiencySemantic informationAdultsTau pathologyAD pathophysiologyParticipantsPET dataFunctional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults
Uquillas F, Jacobs H, Schultz A, Hanseeuw B, Buckley R, Sepulcre J, Pascual-Leone A, Donovan N, Johnson K, Sperling R, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cerebral Cortex 2019, 30: 1974-1983. PMID: 31696223, PMCID: PMC7132950, DOI: 10.1093/cercor/bhz217.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCognitively unimpaired older adultsMetamemory processesMemory performanceOlder adultsMidline regionVentromedial prefrontal cortexFunctional magnetic resonance imaging signalsHarvard Aging Brain StudyJudgments of learningAging Brain StudyAlzheimer's diseaseMemory successPrefrontal cortexAssociated with overestimationNeural substratesTau pathologyBilateral hippocampiBrain studiesJOLsCohort of older adultsMagnetic resonance imagingCognitionAD dementiaTau depositionRegional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1
Labayru G, Diez I, Sepulcre J, Fernández E, Zulaica M, Cortés J, de Munain A, Sistiaga A. Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1. NeuroImage Clinical 2019, 24: 102078. PMID: 31795042, PMCID: PMC6861566, DOI: 10.1016/j.nicl.2019.102078.Peer-Reviewed Original ResearchConceptsGlobal gray matterDiffusion tensor imagingCTG expansion sizeSubcortical regionsWhite matter lesionsMyotonic dystrophy type 1Fractional anisotropyStructural brain signaturesBrain atrophyAssociated with cognitive impairmentStructural cerebral changesAssociation cortical regionsDegree of muscular impairmentMicrostructural WM abnormalitiesVoxel Based MorphometryWhite matterHealthy controlsDM1 patientsRegional brain atrophyType 1Global white matterIQ estimatesNeuropsychological profileGM reductionNeuropsychological scoresMulti-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury
Wooten D, Ortiz-Terán L, Zubcevik N, Zhang X, Huang C, Sepulcre J, Atassi N, Johnson K, Zafonte R, Fakhri G. Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury. Journal Of Neurotrauma 2019, 36: 3233-3243. PMID: 31210098, PMCID: PMC6857466, DOI: 10.1089/neu.2018.6178.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryTraumatic brain injury subjectsDistribution volume ratioWhite matter integrityFunctional connectivityDiffusion tensor imagingPositron emission tomographyTBI subjectsResting-state functional magnetic resonance imagingResting state functional connectivityFunctional magnetic resonance imagingFractional anisotropyDecreased white matter integrityGroup of TBI subjectsIncreased functional connectivityFunctional MRI resultsGraph theory metricsBrain injuryLiving human brainMagnetic resonance imagingNoninvasive neuroimaging techniquesBrain regionsFunctional MRINeuroimaging techniquesDiffusion tractography imaging
2018
Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology
Grothe M, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel S, Initiative A. Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology. Brain 2018, 141: 2755-2771. PMID: 30016411, PMCID: PMC6113636, DOI: 10.1093/brain/awy189.Peer-Reviewed Original ResearchConceptsRegional gene expression profilesGene expression profilesAlzheimer's disease pathologyExpression profilesPathophysiological mechanism of Alzheimer's diseaseDisease pathologyAlzheimer's diseaseAmyloid depositsExpression levelsMechanisms of Alzheimer's diseaseHuman brain transcriptomeGene set enrichment analysisTau kinasesAlzheimer's Disease Neuroimaging InitiativeMicroarray measurementsTau proteinMAPT expressionAllen Brain AtlasGene setsAmyloid precursorBrain transcriptomeRas-ERKNeurofibrillary degenerationRegionally selective vulnerabilityMitochondrial respirationPET staging of amyloidosis using striatum
Hanseeuw B, Betensky R, Mormino E, Schultz A, Sepulcre J, Becker J, Jacobs H, Buckley R, LaPoint M, Vannini P, Donovan N, Chhatwal J, Marshall G, Papp K, Amariglio R, Rentz D, Sperling R, Johnson K, Initiative F, Study A. PET staging of amyloidosis using striatum. Alzheimer's & Dementia 2018, 14: 1281-1292. PMID: 29792874, PMCID: PMC6219621, DOI: 10.1016/j.jalz.2018.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesAmyloidosisApolipoprotein E4Brain ConcussionCognitive DysfunctionCorpus StriatumDisease ProgressionFemaleFollow-Up StudiesHumansImage Interpretation, Computer-AssistedLongitudinal StudiesMalePositron-Emission TomographyProspective StudiesSeverity of Illness IndexConceptsPositron emission tomographyHippocampal volumeCortical amyloidInvolvement of cortexPositron emission tomography dataStriatal signalingPositron emission tomography classificationAmyloid positron emission tomographyStriatumCognitive declineCortical measuresCortexPostmortem dataCognitionCortical depositsEmission tomographyIncreased predictive powerDementia progressionAdvanced amyloidosisDementia researchAlzheimerPET dataStriatalFollow-up dataPredictive powerStructural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs H, Hedden T, Schultz A, Sepulcre J, Perea R, Amariglio R, Papp K, Rentz D, Sperling R, Johnson K. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience 2018, 21: 424-431. PMID: 29403032, PMCID: PMC5857215, DOI: 10.1038/s41593-018-0070-z.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory declineCingulate cortexHippocampal volumeTau accumulationAssociated with increased mean diffusivityCognitively healthy older individualsBaseline hippocampal volumeAmyloid-positive individualsWhite matter connectivityAmyloid-negative individualsPreclinical Alzheimer's diseaseAmyloid pathologyAnimal models of Alzheimer's diseaseHealthy older individualsTau pathology propagationModel of Alzheimer's diseaseAlzheimer's diseaseTau positron emission tomographyMemory performanceNeural vulnerabilityCingulum bundleOlder individualsPositron emission tomographyMean diffusivity
2017
In vivo staging of regional amyloid deposition
Grothe M, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel S, Initiative F, Initiative A, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. In vivo staging of regional amyloid deposition. Neurology 2017, 89: 2031-2038. PMID: 29046362, PMCID: PMC5711511, DOI: 10.1212/wnl.0000000000004643.Peer-Reviewed Original ResearchConceptsAmyloid depositionAmyloid pathologyVivo stagingCognitive impairmentPrimary sensory-motor areasAmyloid stagesRegional amyloid depositionCSF Aβ42 levelsAlzheimer's disease dementiaSensory-motor areasAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortNormal older individualsMedial temporal lobeMild cognitive impairmentAβ42 levelsDisease dementiaNeuropathologic observationsInitiative cohortAmyloid positivityTemporal lobeFull cohortCN individualsAssociative neocortexBrain regionsOlder individualsComplexity analysis of cortical surface detects changes in future Alzheimer's disease converters
de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters. Human Brain Mapping 2017, 38: 5905-5918. PMID: 28856799, PMCID: PMC5745046, DOI: 10.1002/hbm.23773.Peer-Reviewed Original Research