2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAllelesConnectomic-genetic signatures in the cerebral small vessel disease
Gutiérrez-Zúñiga R, Diez I, Bueichekú E, Kim C, Orwig W, Montal V, Fuentes B, Díez-Tejedor E, Fernández M, Sepulcre J. Connectomic-genetic signatures in the cerebral small vessel disease. Neurobiology Of Disease 2022, 167: 105671. PMID: 35231560, PMCID: PMC8957615, DOI: 10.1016/j.nbd.2022.105671.Peer-Reviewed Original ResearchMeSH KeywordsBrainCerebral Small Vessel DiseasesConnectomeCross-Sectional StudiesGray MatterHumansMagnetic Resonance ImagingWhite Matter
2017
In vivo staging of regional amyloid deposition
Grothe M, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel S, Initiative F, Initiative A, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. In vivo staging of regional amyloid deposition. Neurology 2017, 89: 2031-2038. PMID: 29046362, PMCID: PMC5711511, DOI: 10.1212/wnl.0000000000004643.Peer-Reviewed Original ResearchConceptsAmyloid depositionAmyloid pathologyVivo stagingCognitive impairmentPrimary sensory-motor areasAmyloid stagesRegional amyloid depositionCSF Aβ42 levelsAlzheimer's disease dementiaSensory-motor areasAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortNormal older individualsMedial temporal lobeMild cognitive impairmentAβ42 levelsDisease dementiaNeuropathologic observationsInitiative cohortAmyloid positivityTemporal lobeFull cohortCN individualsAssociative neocortexBrain regionsOlder individualsHierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distributionThe association between tau PET and retrospective cortical thinning in clinically normal elderly
LaPoint M, Chhatwal J, Sepulcre J, Johnson K, Sperling R, Schultz A. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage 2017, 157: 612-622. PMID: 28545932, PMCID: PMC5772972, DOI: 10.1016/j.neuroimage.2017.05.049.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAtrophyCarbolinesCerebral CortexCross-Sectional StudiesFemaleFollow-Up StudiesHumansMalePositron-Emission TomographyTau ProteinsConceptsTemporal regionsCortical thinningCortical ROIsCortical thicknessRetrospective longitudinal analysisRight temporal regionAssociated with neuronal lossBaseline ageNormal cohortNeuronal lossRate of cortical thinningLeft cuneusPathologyMedial temporal regionsVolumetric ROIsReference regionAtrophyThick cross-sectionsCortical regionsBilateral parahippocampal cortexLongitudinal atrophyLongitudinal analysisLeft superior temporal sulcusCortexBrain studies
2013
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations
2006
Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study
Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle G, Miller D, Thompson A. Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study. JAMA Neurology 2006, 63: 1175-1180. PMID: 16908748, DOI: 10.1001/archneur.63.8.1175.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyCerebral CortexCross-Sectional StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveConceptsPrimary progressive MSMultiple sclerosisBilateral thalamic atrophyYears of follow-upPrimary progressive multiple sclerosisYears of symptom onsetHealthy control subjectsGray matterProgressive multiple sclerosisDecreased GM volumeGradient-recalled echo sequenceMagnetic resonance imagingInfratentorial atrophyCross-sectional studyVoxel-based morphometric analysisInfratentorial areaDeep GMThalamic atrophyComparing patientsControl subjectsFollow-upProgressive MSSymptom onsetGray matter atrophyLesion load