2024
Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patterns
2023
Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Journal Of Neuroscience 2023, 44: e0488232023. PMID: 38123362, PMCID: PMC10869152, DOI: 10.1523/jneurosci.0488-23.2023.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyCognitive changesCognitive declineAssociated with cognitive changesAssociated with early cognitive declineAging Brain StudyEarly cognitive declineTau depositionCognitive scoresBrain studiesHuman brainTau pathologyOlder adultsTau accumulationTau associationImpaired associationAD symptomsClinical trajectoryCortical patternsTauBraak stageSpatiotemporal levelsTemporal accumulationBraakFuture increases
2021
Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia
Dong D, Yao D, Wang Y, Hong S, Genon S, Xin F, Jung K, He H, Chang X, Duan M, Bernhardt B, Margulies D, Sepulcre J, Eickhoff S, Luo C. Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia. Psychological Medicine 2021, 53: 771-784. PMID: 34100349, DOI: 10.1017/s0033291721002129.Peer-Reviewed Original ResearchConceptsCognitive functionBottom-up sensory informationVentral attention regionsExecutive brain regionsExecutive control processesCharacteristics of schizophreniaFrontal-parietal regionsSensory processing deficitsResting-state fMRIImpaired sensory processingSomatosensory-motor systemHypo-connectivityConnectome gradientProcessing deficitsHierarchy organizationTransmodal networksFronto-parietalAttentional demandsBrain areasBrain regionsSchizophreniaMacroscale hierarchySensorimotor regionsHyper-connectivityAffective integration
2019
Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiology Of Aging 2019, 88: 51-60. PMID: 31941578, PMCID: PMC7085436, DOI: 10.1016/j.neurobiolaging.2019.12.005.Peer-Reviewed Original ResearchConceptsAssociated with lower global cognitionCognitive impairmentAlzheimer's diseaseBrain network dysfunctionAD-related changesMild cognitive impairmentFrontoparietal networkSalience networkMode networkStrength of connectionsNetwork-based investigationsGlobal cognitionNetwork dysfunctionAD-related conditionsBrain connectivityConnectivity changesCortical regionsConnection distanceInvestigation of brain connectivityAD spectrumVoxel levelHealthy controlsDistance of connectionBrainPathways of connectivityFunctional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults
Uquillas F, Jacobs H, Schultz A, Hanseeuw B, Buckley R, Sepulcre J, Pascual-Leone A, Donovan N, Johnson K, Sperling R, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cerebral Cortex 2019, 30: 1974-1983. PMID: 31696223, PMCID: PMC7132950, DOI: 10.1093/cercor/bhz217.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCognitively unimpaired older adultsMetamemory processesMemory performanceOlder adultsMidline regionVentromedial prefrontal cortexFunctional magnetic resonance imaging signalsHarvard Aging Brain StudyJudgments of learningAging Brain StudyAlzheimer's diseaseMemory successPrefrontal cortexAssociated with overestimationNeural substratesTau pathologyBilateral hippocampiBrain studiesJOLsCohort of older adultsMagnetic resonance imagingCognitionAD dementiaTau depositionSensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder
Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos F, Pretus C, Villarroya Ó, Pina-Camacho L, Díaz-Caneja C, Parellada M, Arango C, Desco M, Sepulcre J, Carmona S. Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 422-433. PMID: 31260788, DOI: 10.1016/j.jaac.2019.05.033.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAutism spectrum disorder groupHigh-functioning ASD individualsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsVineland Adaptive Behavior ScalesUnimodal regionsImpaired multisensory integrationAssociated with increased clinical severityMultisensory integration deficitsAdaptive Behavior ScalesFunctional connectivity analysisSocial Communication QuestionnaireSocial Responsiveness ScalePatterns of hyper-Connection integrityMultimodal sensory integrationFunctional dysconnectivityBrain systemsASD groupMode networkFronto-parietalHigh-functioning
2018
Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain
Diez I, Sepulcre J. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain. Nature Communications 2018, 9: 3876. PMID: 30250030, PMCID: PMC6155203, DOI: 10.1038/s41467-018-06346-3.Peer-Reviewed Original ResearchConceptsWhole-brain functional connectivityCognitive statesDepression-related genesDynamic connectivity patternsLong-term potentiationResting stateSynaptic long-term potentiationNeurobiological basisGraph theory-based analysisHeteromodal cortexFunctional connectivityPrimary sensory areasNeural activityAttention areasConnectivity patternsConnectivity dynamicsHuman brainSensory areasGenetic transcription levelsDMNTheory-based analysisDynamic connectivityDynamic streamsLocal networkTask
2015
Sensation‐to‐cognition cortical streams in attention‐deficit/hyperactivity disorder
Carmona S, Hoekzema E, Castellanos F, García-García D, Lage-Castellanos A, Van Dijk K, Navas-Sánchez F, Martínez K, Desco M, Sepulcre J. Sensation‐to‐cognition cortical streams in attention‐deficit/hyperactivity disorder. Human Brain Mapping 2015, 36: 2544-2557. PMID: 25821110, PMCID: PMC4484811, DOI: 10.1002/hbm.22790.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAttention-deficit/hyperactivityCognitive circuitsConnectivity streamsResting-state functional magnetic resonance imaging dataFunctional magnetic resonance imaging dataExecutive processing areasFunctional connectivity differencesIncreased degree of connectivityLocal sensory processingMagnetic resonance imaging dataPrimary sensory cortexExecutive regionsConnectivity differencesDecreased connectivityFunctional connectivityExecution processSensory processingGraph theory methodsCortical streamSensory cortexProcessing areasPrimary cortexCortexInternal sources of information
2014
Functional Streams and Cortical Integration in the Human Brain
Sepulcre J. Functional Streams and Cortical Integration in the Human Brain. The Neuroscientist 2014, 20: 499-508. PMID: 24737695, DOI: 10.1177/1073858414531657.Peer-Reviewed Original ResearchConceptsProcessing of brain informationHuman brainBrain functional connectomeFunctional streamsBrain systemsCortical hubsFunctional connectomeHuman cognitionOrganization of neuronal networksSensory cortexCortex areaCortical integrationBrainMotor cortex areaNeuronal interactionsNeuronal networksBrain informationCognitionCortexConnectome
2010
Functional-Anatomic Fractionation of the Brain's Default Network
Andrews-Hanna J, Reidler J, Sepulcre J, Poulin R, Buckner R. Functional-Anatomic Fractionation of the Brain's Default Network. Neuron 2010, 65: 550-562. PMID: 20188659, PMCID: PMC2848443, DOI: 10.1016/j.neuron.2010.02.005.Peer-Reviewed Original ResearchConceptsMedial temporal lobe subsystemNetwork of brain regionsBrain's default networkHuman functional imagingPersonally significant eventsDefault networkMidline coreSelf-relevanceMental sceneSpontaneous cognitionBrain regionsFunctional imagingSpontaneous actsSignificant eventsCognitionIntrinsic activityMemoryDecision makingBrainHypothesis